Any compounds discussed may be intended for research purposes only. Nothing here is a protocol to follow — amounts, timing and cycle lengths are reported as the named speaker described them.
In this episode
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Episode notes
Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down two of the most underrated fat-burning peptides out there — HGH Fragment 176-191 and AOD 9604 what makes them different, how to use them, and why they deserve a spot in your cutting stack.
Chapters:
We cover:
🧬 What these peptides actually are
– Both are fragments of the full 191 amino acid HGH chain
– HGH Frag 176-191 = the natural amino acid sequence (176–191)
– AOD 9604 = lab-engineered version (177–191), modified for longer duration and better safety profile
– AOD received FDA GRAS (Generally Recognized As Safe) status in 2014
– Developed at Monash University in Australia 🇦🇺
🔥 What they do (and what they don't)
– Target lipolysis — fat burning, especially visceral/abdominal fat
– Boost metabolism and increase energy expenditure
– No IGF-1 spike
– No hypoglycemia risk
– No effect on growth — zero cancer concern
– 30–50% greater fat reduction vs controls in studies
– Obese participants lost significantly more body fat vs placebo over 12 weeks
⚖️ HGH Frag 176-191
– Natural fragment of the HGH chain
– Half-life: ~30 minutes
– Can dose 1–2x daily (some go 3x)
– Best taken fasted — morning or pre-workout
– Cycle length: 8–12 weeks
– Comes in 5mg bottles (they don't like water — keep it small)
👑 AOD 9604
– Lab-engineered, modified for longer stability
– Half-life: 30–60 minutes
– Daily dosing (can split AM/PM)
– Additional benefit: potential cartilage and joint repair (not seen with HGH Frag)
– Cycle length: 12–16 weeks
– FDA GRAS status — one of the safest peptides available
– JD's personal top 5 — shines brightest stacked with other cutting compounds
🚫 What NOT to combine
– High-dose corticosteroids
– Full-dose HGH (defeats the purpose of the targeted safety advantage)
– Insulin (just don't)
✅ What pairs great with these
– GLP-1 agonists (Semaglutide, Tirzepatide)
– 5-Amino-1MQ
– L-Carnitine
– BPC-157 + TB-500 (especially with AOD for joint/cartilage synergy)
– CJC + Ipamorelin (boosts metabolism and fat burning further)
🧠 Real-world take
– AOD shines brightest when stacked — it's a force multiplier for your cutting stack
– HGH Frag works fast and hits hard on a short half-life
– Both are tools — results depend on diet, training, and what you stack them with
– Individual response varies — don't let your gym bro's experience dictate yours
🔑 Bottom line: If you want pure fat burning with virtually zero downsides, these two are as clean as it gets.
🧪 This isn't theory this is real-world experience working with hundreds of people and seeing what actually works.
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Will's Instagram: https://www.instagram.com/williamthaas/
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Compounds discussed
From the transcript
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