Peptide Q&A #43 – Mitochondrial Stack Order, Sleep & Cortisol, Bone Density & Body Recomposition

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover the right order for mitochondrial peptides, why sleep and cortisol matter more than any compound, switching from Tirzepatide to Retatrutide, bone density protocols, and what body recomposition actually looks like on the scale.

Chapters:

00:00 – Intro, Parenting & Little League Stories

06:49 – Vegas Plans & Podcast Setup

07:33 – Modafinil Explained (Focus & Energy)

14:58 – Benefits, Side Effects & Dosing

20:08 – Dihexa & Brain Health

26:17 – CMAX Breakdown & Brain Fog

31:16 – CLANK for Anxiety & Focus

36:20 – Which Nootropic Should You Use?

40:51 – FDA Status, Safety & Duration

43:30 – Stacking Protocols & Best Uses

46:52 – Upcoming Genoshack Podcast & Outro

We cover:

• Switching From Tirzepatide to Retatrutide: Why at low doses you can swap directly and why more frequent dosing beats once a week

• Tesofensine for Anxiety & GLP Transition: Why it's the best next step coming off GLPs and what to watch for if anxiety is already a factor

• Mitochondrial Stack Order: Why SS-31 comes before MOTS-C every time, what FOXO4 does, and why lifestyle fundamentals come before any peptide

• HGH Debate — Worthless or Essential?: Why HGH is a long play, why secretagogues lose effectiveness as the pituitary ages, and why real HGH wins for men over 40

• Which HGH Is Actually Best: Why Somatropin, Serostim and Genotropin are all identical and what the different kit sizes actually mean

• Firefighter Sleep & Cortisol Protocol: Why cortisol takes the top seat over testosterone, the supplement stack that fixed JD's sleep, and why sunlight and grounding still matter

• Tesamorelin + Retatrutide for Visceral Fat: Dosing both together, why gaining weight but losing inches is actually the goal, and what body recomposition really looks like

• Perimenopause Protocol Simplified: Why the Klow blend, TA-1, NAD, SS-31 and creatine cover most bases with minimal injections

• Bone Density & Osteopenia at 59: Why HGH plus resistance training beats calcium advice, and what's emerging in bone-specific peptide research

• Insulin Resistance, Anxiety & Tirzepatide in a 30-Year-Old: Why blood sugar normalizing feels like hypoglycemia, why switching to Retatrutide helps, and why NAD can worsen anxiety in some people

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