Ep 27 · 36:36
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Research use only
Any compounds discussed may be intended for research purposes only. Nothing here is a protocol to follow — amounts, timing and cycle lengths are reported as the named speaker described them.
We are not doctors. Use at your own risk.
0:14Speaker 0This is the Q and A episode. I'm your host, JD Denham. I got my buddy and my co host across the way, William T. Hoss. Happy Friday, brother. Happy Friday.
0:24Speaker 0The eve of vacation for me. Yeah, I was gonna let everybody know if Will seems a little extra chipper today, it's because he is going with his girlfriend to the big island of Hana, Hawaii, which I have been multiple times. So he's been in a week with his girlfriend and his girlfriend's family,
0:46Speaker 0Yes. And I don't know about extra chipper, but like maybe a little bit stressed out because I have a whole bunch of stuff to do before I go. I wasn't gonna shine a light on that, but yeah, when he, when he logged on today, he seemed stressed and I'm like, You're off, dude. He said, Yes, I'm off. So,
1:01Speaker 0but hey man, at the end of the day, everything's perspective. You're going to Hawaii. So good
1:10Speaker 0I don't know when I won't talk for Will, but I will talk for myself. I enjoy this Q and A. I like to see the questions people ask and the things people are researching and things like that. And I love talking about this stuff, man. I've always loved it. Will and I have been talking about supplements
1:26Speaker 0and such for very long time. So now we just do it on a podcast. How cool is that? That's cool, man. And I agree.
2:04Speaker 0you have to do a little bit of your own research on yourself because it's not 1 shoe fits all. You have to find what is your sweet spot on testosterone replacement
2:16Speaker 0And it takes time, man. You can't just say, well, this works for me, so it's going to work for you. You have to see if it works for you and go from there. So kind of a cool little
2:25Speaker 0enter into the questions because we have some of those that are going to be based on that,
2:30Speaker 0but he's got to get some work done so he can get out of here and get ready for his trip. You wanna start us off, big dog? Sure. I gotcha.
3:06Speaker 1looking to cut a decent amount of weight around 40 pounds. My question is, should I start with Retatrut or Tesamorelin?
3:21Speaker 0It's awesome that you're getting back to the gym. We obviously are huge supporters of any type of exercise.
3:33Speaker 0Without a doubt, we've said it multiple times. I'll say it again. It is a damn scientific
3:38Speaker 0breakthrough in regards to what it does, not just in regards to helping you lose that 40 pounds, but your brain's gonna feel sharper.
3:46Speaker 0You know, you're gonna eat less. You're still gonna have, you know, get hungry. You're just gonna eat less. So it's gonna really help you. So my answer will be absolutely on the Retatrutide
4:05Speaker 0It really focuses in right on that bottom belly fat. So you could be taking Retta 3 times a week. You can throw in some Tesamorelin at night. There you go. They go perfectly together.
4:27Speaker 1but you could take both if you are, but Reta's gonna be much more effective for your purposes. It's a good idea to be taking your test along with it because you're gonna be eating less. Reta helps a bit, so does the Tesamorelin of not going like catabolic. Right? So
4:54Speaker 0All right. I am looking into the shred stack. Was wondering how long is that supply last? Well,
5:01Speaker 0that's kind of depending on what company that you're looking at. Why don't you, if you have follow me on Instagram, JD-ten-them fit, shoot me a DM there and I can give you some wisdom on some of the companies that I use.
5:13Speaker 1All right. Hi, I have been enjoying the podcast and have learned a lot from both of you. Recently, you've mentioned that some peptides benefit from different mills of backwater
5:24Speaker 1Do you have all of this information in 1 place, or would you be willing to do a rundown? For example, 5 or 10 mg vials of AOD-nine
5:36Speaker 1sometimes 2 ml seems preferential, and sometimes 3. Would appreciate best practice tips. Also, do you have thoughts on bioglutide,
5:44Speaker 1or have you played around with it yet? Thank you so much. Good question. Go ahead, brother. Very good question.
6:03Speaker 1It does not really like to mix in with water very well. Right? But the goal is to, you have to add enough water for the powder to mix, to mix completely into the water.
6:14Speaker 1Or else we'd be putting, you know, 0.25 of a mil of water because who wants to inject a whole bunch, but it would also make the measurements tough. So it
6:24Speaker 1how much water you put in as far as the efficacy of any peptide. What does matter though, is if you put a different amount of water in, you better be able to do the math correctly, right? How much it's diluted
6:50Speaker 1everything is a bit different because different and you gotta know like, hey, if it's a peptide that like VIP
6:55Speaker 1that you need to take a tiny amount, right, like a 200. Bless you. Yeah. And you need to you better put in all 3 mils of water or else there's no way you're gonna measure
7:26Speaker 1There's information there, but there's information all over the website or the Internet on
7:32Speaker 0mixing different things. Now- Yeah. Yeah. Go ahead. You can- I was gonna say, and just so people know, like VIP and things like that's a little bit more, you you need to kind of don't overdo it. But when it comes to the peptides, let's just say that someone suggested protocol
7:52Speaker 0It ain't going be the end of the world if you put 3 mils in it. Just, you know what I mean? People are so stressed about the exact mils. It's going to be fine. It's diluted a bit. And as Will said, you want to do the math, but
8:10Speaker 1out there for every single peptide. You know what I mean? Yeah. And for like, to answer the question, here's an example, like so Retta,
8:26Speaker 1okay, in the 10, if you put 2 ml in the 20 milligramer and you put 3 ml in the 30 milligramer.
8:40Speaker 1will equal the exact same amount in milligrams. You draw 10 units and it will be 1 mg in all 3 of those bottles if you added that correct amount of water. Yep. Because that's what the math tells us.
9:00Speaker 1So I would put at least 2 mils in there. If it is like coagulating or gelling, you can add another mil and just do the math, realize that it's diluted more. 1
9:16Speaker 1here is 1 caution. 1, if you so, so these peptides, the actual peptide powder is like wisps. You would almost barely see it. If somebody gave you a bottle and just had just the peptide in it, you would say, gave me an empty bottle, dude. It looks like you poured things out, turned back over, and it just has the residue. So to make these, they actually add like a salt puck
9:52Speaker 1you add water that's too cold. Okay? If you add water that's too cold, and if you add water too fast,
9:59Speaker 1that can make any peptides directly gel up. The goal here is actually like, you don't want to add hot water, but you know, a little bit cold room temp is probably perfect.
10:17Speaker 1shake this thing, right? They're like live cultures, right? This is almost think of it as like a live organism, right? And it's, they're sensitive. So, know, roll them,
10:27Speaker 1spin it, make sure it gets, it actually gets completely mixed. The colder the water longer it's gonna take to mix. If you run into, if you put water in there and it starts to, and it is gelling up,
10:39Speaker 1Right? Swirl it up a little bit more. Don't let your peptide just sit also in your, in, you know, for a long, long time, like use it, especially AOD. I don't care how much water you mix in there. If you don't use that in 2 weeks, it's probably going to start gelling up.
10:54Speaker 0Use it. Probably more over any other peptide. AOD- More than anything. It's not mixed well. Yeah. But just to kind of, just 1 more reiteration of what he just said, the important part, if you're putting in your peptides and you are squeezing that water in quickly, you're doing it wrong. Do not do that slowly. They're delicate.
11:10Speaker 0You can tap it. You kind of move it, but you want to go put the water in on the bottle, on the side of the bottle, let it go down very slowly.
11:17Speaker 1And if your peptides are good, they should be vacuum sealed. So, so what I mean by that, it should pull the water out of the, out of the fringe and oftentimes any of that pulls it too fast. So you almost need to like hold the plunger and force it to be a bit slower,
11:41Speaker 1you know, you can put in as many mils of water as you want and still get the same dose. Just put that into the peptide calculator and the math is done for you.
11:57Speaker 0and 1 of the side effects I've noticed is numbness in my fingers. Is there a solution for
12:04Speaker 0your information on seeing great results on it so far? That means it's working. That means that's a good thing. Numb fingers just means it's
12:14Speaker 1Yeah, that's it. It's a long, long time known fact, right? People like doing growth Yes.
12:26Speaker 1maybe like arthritis feeling, like, knuckles should be a bit swollen. Your fingers should be tingly.
12:30Speaker 1That is a good thing. And no, there is no real solution to it. Sorry, but you know that working.
12:43Speaker 1it may be a shock, but you learn to get used to it and that's- Now your body starts to kind of adapt.
12:56Speaker 0we've done this for a long time. I've been injecting testosterone replacement, good 10 years, give or take somewhere around there. And for the longest time I have injected for those who are on YouTube or whatnot can see on the top part of my butt right there's my sweet spot on both sides.
13:26Speaker 0those that can see that little guy, if you can even see it, barely, just tiny. It's 0.5 inch and that guy does not hurt. But if you're gonna inject right in the shoulder, boom.
13:41Speaker 0right? So you're going to take your drawing needle and you're going to use that for your testosterone,
14:09Speaker 0and then you're gonna pull out. You're gonna put some air in. You're gonna push the air in,
14:21Speaker 0and then boom, right in the back of your shoulder, ping, you have used that needle 1 time for your shoulder and you have no issues. You've been cleaning
14:32Speaker 0I like the shoulder pins. I had not used them for years. I've just always done the longer, bigger needles in my butt, but I've been injecting personally in the last year or so into my shoulder. It's been great. What about you, man? Well, so I started using,
15:00Speaker 1the needle. Right? Not lengthwise, but the actual circumference. Yeah. Skinny. Yeah. Yeah.
15:06Speaker 123 gauge, 1 inch, full inch right into your glute and 23 gauge. That's a little bit big. I now
15:13Speaker 1am gonna use I now use 25 gauge, 1 inch if I'm going to your glute. Most people have a little bit of fat on their butt. Okay? So that's why you need to get it deep. 1 inch for your glute is a good idea for 95
15:29Speaker 1because the biggest mistake people make is not going deep enough, frankly, and then you get a little bump on the outside.
15:35Speaker 1So if I go to your glute, you know, I would do it if you're unless you're like ultra lean, I'd use a 25 gauge 1 inch. But shoulders,
16:00Speaker 1And then the subcutaneous is insulin insulin needle. Right? Those come in between like 29
16:12Speaker 131, 30. Yeah. Yeah. Least what I'd say. And that can be done. The problem is with that guy,
16:19Speaker 1won't the tip is not removable and there's no way that you are pulling any oil from. There's no way you can. I'm sorry. It will take a long time. You can take your hours. Now there is a trick because I happen to have a past life use
16:38Speaker 1is not what this is about. But if you wanna use this, like a lot of people do TRT in their like subQ and
16:44Speaker 1daily, and you want to, if you wanna use an insulin needle, just pull up the plunger out the back and
16:55Speaker 1Back in. And now you got it in the insulin unit, and then it will go out after some time pushing, but the suction drawing insulin needle not happening.
17:04Speaker 0We've talked about that too. So if you're gonna be doing testosterone oil in your stomach,
17:09Speaker 0Sub Q, I would definitely do it daily and just so you're doing small amounts. Because if you're going to try to put mil
17:20Speaker 1I like that. And I actually really liked the 1 mil back. It's a lot easier to push debt. It's a lot easier to push in. The 3 mills is just a bigger stopper and
17:30Speaker 1having to just, I don't know. It's scraped the stopper scrapes on the sides oftentimes and makes it a lot harder to go in than that 1 mil.
17:52Speaker 0Right. Mean, generally we're thinking how I would do it is you're going to probably want to use a friend or your wife or your husband or somebody. And because you're going to want to pull up, my wife has some
18:07Speaker 0and she's tiny, you know, and she's got no fat on her. So I have to pinch and pull up her skin. So I put it into that wrist. So if you're doing your hand, I would do it in all around the hand. I would spread it, but you want to have somebody pull up your skin and you can't really do that and inject yourself. So if you want to do it properly,
18:23Speaker 0you probably need somebody else to do it, but spread it all out through the hand in different injections, but pull up that skin is how I would do it. Too? Yep. Yep. And that is still a subcutaneous
18:41Speaker 1Yep, exactly. You're gonna have somebody do it, but you kind of pull up that skin and then put it right in the
18:50Speaker 1but above any muscle in that little water layer. So it's pulling it up and trying to get that needle there. If it's by itself, you can you can, if you want. Kinda. So think needle in by yourself and just get it underneath the skin.
19:10Speaker 0know that everybody at 1st is scared of needles for peptides and whatnot, but let me just tell you, you don't even hardly even feel it. So any type of fears, once you do it once, you're like, oh wow, that's nothing. No.
19:23Speaker 1So no fear. Yeah. But I would absolutely try it for your carpal tunnel. Like I have actually heard from tons of people that it is fixed, including my mother.
19:46Speaker 0that my hands get tingly and sometimes just have that feeling of falling asleep. Is this normal? Yes, we just answered that. Is normal. Should I change the dose? I also noticed this when I tried the MK.
20:04Speaker 1is doing the same thing, right? It's working on your krillin receptor to tell your body to make, which in turn tells your body to make more human growth hormone.
20:11Speaker 1And that rise in HGH is going to, if it is good and if it's working, it's going to make your hands,
20:26Speaker 1I wouldn't, you know, I do know though that there are some people that have that nerve
20:35Speaker 1And people would get like burning down their down the forearms a little bit to the point where they don't wanna do it. I actually have a friend who's a big, big, tough guy, and he says he's going to his doctor and doctor's like, yep, seen that. People actually have surgery for
20:52Speaker 1But that's a rare, rare case. It's not like life threatening and dangerous. It's just a nerve thing. So your body just feels it.
21:15Speaker 1does that person go to, to make sure they're taking the right peptide or what they are trying to achieve?
21:27Speaker 1come out of 1 bottle? I think it means dosages. Many doses come out of 1 bottle? How long does the peptide stay in your system? Very interested in taking peptides for my shoulder and elbow pain because I like to work out. I had been seeing a lot of ads about peptides, but the people are selling them, say that they are not for animals or humans just for research purposes only. That's why I have a question. Are they illegal?
22:33Speaker 1whoever buys that, and that's why they're for research, like for research purposes only, or, and not for human consumption. Okay? Yeah. You're not allowed to sell them and
22:42Speaker 1tell somebody to use them. Okay? Not allowed to sell them for somebody else. Then for research purposes. That's the only way
22:49Speaker 1Then when the consumer gets them, they are not illegal by any means. I walk down the street, if I get pulled over by a police officer and I have peptides on me,
23:18Speaker 1Choose to use them. I've seen enough evidence out there, you know, we've talked to enough people and experimented
23:49Speaker 0I think we got that 1. What's up guys? I'm currently 3 months into my TRT and peptides.
24:11Speaker 0I did a 90 day cycle with Sermorelin and L Carnitine and stopped and now doing Tesamorelin with my TRT. My question is 1
24:35Speaker 0also pre workout, post workout versus dosing only at bedtime. No, I wake up daily at 6AM and my workout scheduled during the week is evenings around 5. That's a great question, man.
25:04Speaker 0just choose to take the Tesamorelin at night. I like to take 20 units and that's my sweet spot. But I also take human growth hormone 2 units and I have for a long time in the morning. So my
25:16Speaker 0answer to that question, and Will might have a different answer, is I like HGH in the morning, right when I wake up and a secret a GOG at night. I do move the secret a GOG around a lot.
25:46Speaker 1Right at night when we're asleep is our biggest pulse. That's why we grow back most of, that's where we do a lot of our healing. The point of Tesamorelin,
25:54Speaker 1what I think is best to be used at night because we really want to amplify that 1 big pulse. Okay. During
26:00Speaker 1the day, our body is not really willing to, it's making these like a few little pulses, but
26:08Speaker 1is going to benefit those pulses enough to really make much of a difference. So I would stay with Tesamorelin just at night.
26:16Speaker 1I would maybe, hey, if the goal is to make is to add some more muscle, right? That's what they said. I would like you some IGF-1LR-three
26:32Speaker 1Ipamorelin is probably also, yeah, better idea. Ipamorelin also activates your ghrelin receptor, which makes you stimulate your your hunger a little bit. So you'll eat a little bit more and therefore
26:56Speaker 0So, yeah, that's a lot. The main justice of that question though, what this guy's doing that I think is great is you're getting your hormones in line and you're getting those things structured and we're trying to keep you, all of us, man, are trying to keep our testosterone levels of around a 27 to a 31 year old. Remember how you felt at that time? So it's easier to gain some muscle and things like that at that time. So you're doing it right, man. I like the question.
27:22Speaker 0on yourself and I think it's great. You're heading heading in the right direction. You know, I would say though that you're averaging at 1,200 to 1,300
27:29Speaker 1nanograms per deciliter. Kinda high, but you know what? I mean, hell, dude. I know people whose doctors said, Hey, that's the goal that we're gonna keep you. You know, I kind of in my, I'm trying to aim myself for maybe about 900.
27:51Speaker 1I mean, not range, but that's kind of where we should be about 1,200, right? When we're, we're- Why I said 31 year old. Right.
27:58Speaker 1So a little bit less than that maybe, but, but it's, everybody is different, man. If you can, I guess the point is
28:05Speaker 1number 1 thing that we worry about is fertility, right? Long term testosterone use, especially at an
28:12Speaker 1elevated amount is at 1 3 -six year old, you're most likely gonna wanna have kids. So think on that. You've already had kids and you don't care, then great. That opens you up to more things, right? Number 2, maybe also number 1, but estrogen,
28:25Speaker 1right? You need it. You just don't want to be doing so much testosterone where you cannot manage your own estrogen.
28:30Speaker 1Now, you know, aromatase inhibitors, I think everybody should be taking them because everybody at over,
28:45Speaker 1But everybody is different, right? Some people get it at a 100 mix, right? Some people can do a lot more and not have estrogen. But as long as you're managing your estrogen, you're getting your blood test, you're not worried about fertility
29:04Speaker 0Off energy level, like go off. My thing is 900 is generally my sweet spot, but it has taken me years to find my sweet spot. And it just takes time to kind of do this stuff. We've said it multiple times, but it's not 1 size fits all just because this guy said at the gym told you to do this. You have to figure it out yourself. And that's why I like that question. I think that you are, I think you're searching.
29:26Speaker 1also make sure that you are not seeing just your total test, which are free testosterone because that's what actually
29:35Speaker 1Okay. Hi. I've been injecting peptides for about 6 months now. I have tried all the popular and fan favorites. I love them all. My husband is 53, college athlete, continues to play in men's basketball leagues.
29:52Speaker 1Would love for him to try all of the healing and anti inflammatory pups as well as TRT,
30:06Speaker 1If this were either of you, would you take peptides or stay away just to be on the safe side? Thanks for all the input and information that y'all provide. Great question.
30:18Speaker 0And it's just gonna be a matter of opinion and I'm just gonna air, I'm 48 years old at this point. I'm just gonna air on the safe side. I just would stay away from it. You you have the prostate cancer, which is hormone based in
30:30Speaker 0certain areas. So I would personally stay away from it. Stay away from what? Testosterone
30:36Speaker 0replacement. Testosterone. All right. Yeah, testosterone replacement. And now in regards to peptides,
30:54Speaker 0in regards to hormone levels or things like that. Absolutely do it. But I personally would stay away from testosterone replacement and any growth hormone peptides. Yeah.
31:04Speaker 1I'm going to, I know somebody who's gone to the doctor and he has had cancer before and his doctor told him, No, you can't do any peptides. Now, if it's me,
31:43Speaker 1The testosterone, I'd stay away from it. I would also stay away from HGH, actual HGH or any of the HGH secretagogues,
31:54Speaker 1TB, the healing ones that probably I mean, besides tests, yeah, man, he's definitely a benefit from that. But if he's active, he used to play he used to play real sports, and now he's, you know, still going strong and the weekends did BPC and TB.
32:18Speaker 1beat down, right, from all the sports I used to play, and I still try to go at it. But, man, it's a godsend.
32:25Speaker 0They really are. And it's just- I would be okay with that. I would, and so many people know this, but I had my 1st doctor's appointment, which was virtual today, this morning, and it's been a week since my surgery and I have been taking heavy
32:41Speaker 0And even the nurse practitioner that I was speaking with today was blown away by how I was explaining how great I feel.
32:55Speaker 0do well after the surgery, but when I was explaining to her how well I was doing, moving around things like that, she
33:02Speaker 0was blown away by it. I'm going to tell you that I believe that has a big piece of it. I really do. That's why I have been doing it, and
33:09Speaker 0it's 1 of the reasons why I did that and I'm doing a hyperbaric chamber for my 5th time today. I believe in that as well. We can heal well, we can age well, we just have to be intelligent and there are a lot of studies on this stuff that they work.
33:28Speaker 0All right. You want me to take us out? Yeah, sure. Take us out. Last question, my friends. All right. Can I take SLU tablets
33:39Speaker 095 no DAC at the same time? Easy mouth? Absolutely. Of course you can. Yes. As you should.
34:06Speaker 1Agreed. Absolutely. You can, you can, and, yeah, you should. It'll help. They do they do completely
34:26Speaker 1underneath your tongue tablets are the is the absolute way to go for your SLU- That's my favorite too. That's my favorite, and that is on paper says that's
34:37Speaker 0which is pretty rare among most these peptides. Right? Like I see- Oh, the only peptide that it really probably does better in like a pill form. Yeah. Which is, I mean, I'll tell you what, I have SLU- I have SLU injectables and I have the sublinguals and I,
34:50Speaker 0haven't been doing the injectables. I think the SLU- under the tongue works great. I love it.
35:01Speaker 0guys is going on vacation, but guess, guess what? We are not going to skip a beat. He's going to be doing the podcast next week on a beach in Hana, Hawaii,
35:11Speaker 0you know, so good on him. He works his butt off. I know him well and he deserves it. So we will be doing the podcast,
35:28Speaker 0on any type of way that you can get ahold of us and we will go through them all, but if there's a lot of people asking for the same 1, we'll knock those out 1st.
35:41Speaker 1Kona is in Maui, I believe, the road to Hana. Oh, you're right. It is Hana. I got a mix.
35:59Speaker 1oh, I just work hard. I haven't taken vacation for 5 years. Right? Be tough, you know, try and be tough without. I tried to do that stuff. Like,
36:16Speaker 0Good stuff. So Oh, man, have fun, man. We'll still be doing the podcast next week, but other than that, bro, enjoy your time. And for everybody else,