Any compounds discussed may be intended for research purposes only. Nothing here is a protocol to follow — amounts, timing and cycle lengths are reported as the named speaker described them.
In this episode
15 chapters. Timecodes play from that moment.
Episode notes
Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with their personal functional medicine doctor and longtime friend, Dr. Scott Collie, for a deep dive into blood work, cardiovascular health, gut health, thyroid, and what actually matters when you are running gear or peptides.
Chapters:
We cover:
🩺What functional medicine actually looks at
– Standard doctor panels are a snapshot, not a full picture
– Dr. Scott runs up to 75 markers including cardiovascular, inflammatory, kidney, thyroid, and gut markers
– Most insurance doctors stop at LDL and HDL, missing the full story completely
– You need particle size, not just cholesterol weight, to understand your true cardiovascular risk
🫀 Cardiovascular markers that matter
– APOB: umbrella marker for all arteriosclerotic particles including VLDL, LDL, and IDL
– Particle size is critical: anabolic steroids shift particles to small dense LDL, the type that sticks and clogs arteries
– Myeloperoxidase and LP-PLA2: direct markers of vascular inflammation most doctors never run
– Triglycerides plus elevated liver enzymes (AST/ALT) almost always means fatty liver, no ultrasound needed
– Fibrinogen: a clotting protein made by the liver, high fibrinogen plus high insulin plus high triglycerides is a walking time bomb, especially for steroid users
– CRP (C-Reactive Protein): one of the best inflammatory markers available, if it is high something serious is going on
🧬Homocysteine, the underrated killer
– Homocysteine scars the inside of your arteries so plaque particles can park and stick
– Now being studied as an Alzheimer's marker as well
– Dr. Scott wants it at 7 or below, many people are at 9 to 50
– Fix: methylate with B6, B12, and methyl folate, simple and cheap
– TRT alone will elevate homocysteine, so methylating is a must for anyone on testosterone
⚖️Retatrutide and rapid fat loss, what to watch
– Losing fat very fast can back up bile flow and cause gallstones, not kidney stones
– Check alkaline phosphatase and GGT before starting Reta if there is any gallbladder history
– Signs of gallbladder issues: bloating, belching, pain under right rib cage, high-fat meal distress, floating stools
– Floating poop is not a good sign, it means fat is not being absorbed properly
– Blood sugar, triglycerides, and inflammatory markers improve dramatically and quickly on Reta
🩸Blood work timing for gear users
– Best time to test: before the cycle starts, to establish your baseline
– After the cycle ends: retest to confirm you returned to baseline
– Mid-cycle testing will look alarming by design, be ready for that
– If you do not know what different esters are, you are not ready to run gear
Follow Dr. Scott Collie:
Website: https://heydrscott.com/
Facebook: https://www.facebook.com/DrScottCollie/
Instagram: https://www.instagram.com/hey_dr_scott/
Join The Community: https://www.skool.com/peptideoftheweekcommunity
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Compounds discussed
From the transcript
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