Peptide of the Week: Tesofensine & Methylene Blue – Mood, Focus & Appetite Control Peptide of the Week https://peptideoftheweekpod.com/episodes/peptide-of-the-week-tesofensine-methylene-blue-mood-focus-appetite-control/transcript We are not doctors. The content on this site is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Amounts, timing and cycle lengths below are reported as the named speaker described them. Nothing here is a protocol to follow. --- 0:09 Speaker 0: What is up, everybody? Welcome back to the Peptide of the Week podcast. 0:13 Speaker 0: I am your host, JD Denham. And now sitting right next to me is my buddy and my cohost, 0:19 Speaker 0: William T. Haws. 0:21 Speaker 0: Dude, what's up, man? What's up, dude? It's Friday. I 0:25 Speaker 0: was thinking this morning, man. We got a lot going on. We're juggling a lot. And, you know, Andy, who's our videographer, 0:32 Speaker 0: sent us a cool video that I was looking at this morning. 0:35 Speaker 0: So I want to kind of take a little bit of a side note and ask you a little bit of a different question today. We are coming up at the end of a year and we're going into 2026. 0:44 Speaker 0: Let's let everybody at home know what are some of the things that you're grateful for? 0:49 Speaker 0: Boy. Because you got a lot going You got a lot going on, dude. And I've known you a long time and your life has changed pretty radically 0:55 Speaker 0: well, I've known you to be a long time. So And I thought I'd throw that at Well, you the 1st simple answer that I, like, start every day with is like, 1:06 Speaker 1: 1st of all, I guess I'm grateful I have a brain and 1:10 Speaker 1: arms and legs. Right? Grateful I'm born in America. And frankly, 1:16 Speaker 1: you were in America being a white male. I guess I am I've hit the lotto already. And 1:21 Speaker 1: that is when people may have some other 1:24 Speaker 1: problems with that. Now I don't think that 1:26 Speaker 1: white males should be, 1:29 Speaker 1: I don't know, should be discriminated 1:31 Speaker 1: against. 1:33 Speaker 1: But, hey, 1:35 Speaker 1: life is good from there. Right? I live in a gorgeous place. 1:39 Speaker 1: So those are the things, I don't know, every day I'm like, thank God that I can think, 1:43 Speaker 1: right, that I have my legs. 1:45 Speaker 1: But 1:46 Speaker 1: I am at a point where, I guess, my whole over 10 years of addiction and being miserable and having such a tiny little life and it was just me, 1:55 Speaker 1: all I wanted was to have 1:57 Speaker 1: a bigger life and 2:00 Speaker 1: have friends 2:02 Speaker 1: that cared about me and like a wife and kids 2:05 Speaker 1: and 2:07 Speaker 1: yeah, and be busy and just have a lot of things going on, right? And people like trusting me. 2:12 Speaker 1: And then now now I basically have that. Yeah. 2:16 Speaker 1: And 2:17 Speaker 1: still I get ungrateful of like, God, I just want you to have these friends and people. I hate them and people care about me. 2:24 Speaker 1: But I often am able to step back and go, 2:28 Speaker 1: that's dumb. This is what I asked for. 2:30 Speaker 1: This is what I asked for, and I'm living it. So, dude, I don't know. I am grateful that I have a woman that loves me for me 2:39 Speaker 1: and is supportive 2:40 Speaker 1: with everything. I'm grateful I have a 2:43 Speaker 1: kid in my life that I can 2:46 Speaker 1: be a good influence to. 2:48 Speaker 1: Even though he's not my child, but that doesn't matter. He has had not great influences and 2:55 Speaker 1: I don't know. Grateful for all this, all my friends, 2:58 Speaker 1: and just God working 3:00 Speaker 1: in crazy ways. I 3:03 Speaker 1: don't know. I mean, I guess that was the turning point is 3:07 Speaker 1: Finding and and it was really fine when finally get a god and say, everything will be okay as long as I just kind of put some hard work in, right, and just take 1 foot in front of the other and don't try to just force 3:18 Speaker 1: manipulate 3:19 Speaker 1: everything to my will. You know? Sure. 3:23 Speaker 1: But it still takes hard work. Daily. It still takes a daily, 3:27 Speaker 1: like you say, paying the tab. Yeah. But 3:30 Speaker 1: I don't know, man. I'm grateful constantly for for 3:34 Speaker 1: everything 3:34 Speaker 1: in my life. What's on with for everything. 3:38 Speaker 0: Yeah, there's sometimes, 3:39 Speaker 0: you know, with my kids and I'm thinking, I've had these huge moments of gratitude more than ever in the last, 3:45 Speaker 0: specifically few months. There's a lot of cool stuff going on, just family and just life, business, 3:50 Speaker 0: whatever. It's just been a good year in regards to that. 3:54 Speaker 0: Never take your eyes on the prize, man. Anybody 3:57 Speaker 0: that's listening to this know that Will and I have both been sober for a long time and some of the things that we work with are men that are newly sober. 1 of the lessons, I don't know if you do this, but 1 of the lessons I have my, sponsors start with is, when your legs hit where your feet hit the ground, as you're going, whatever you're going to do, go to the, take a, use a restroom or you're going to push coffee, whatever. As soon as your feet hit the ground, you start going through the role of the things that you're grateful for. It's been amazing. It's been amazing to kind of start those things off, man, because the human brain cannot be 4:26 Speaker 0: negative if you're sitting in a pile of gratitude. So good little lessons to kind of, it's good to start like that just because man, we are coming to an end of the year. It's obviously common sense. Everybody has 4:38 Speaker 0: goals 4:39 Speaker 0: and things that they're gonna do in 2026 4:42 Speaker 0: and new year, and unfortunately, 4:44 Speaker 0: most don't follow through with it. 4:47 Speaker 0: Anyways, but we'll kind of go into a segue of what we're talking about here because some of these things will actually have been studied to actually help you- Help achieve some goals. Help you focus and achieve some goals, ironically. It's actually some of the stuff that I read about it, so it's interesting. So today we're gonna talk about 5:01 Speaker 0: 2, they're not peptides, but they are in that category. We're going to talk about Tesofensine 5:07 Speaker 0: and then Methylene Blue. Let's talk about Tesofensine 5:11 Speaker 0: 1st. I know you know, both have taken it and a lot of people love it. It's 5:17 Speaker 0: monoamine 5:18 Speaker 0: reuptake inhibitor. The hell is that? It's 5:22 Speaker 0: gonna boost your dopamine, 5:24 Speaker 0: your mood, your serotonin. 5:26 Speaker 0: It's really just gonna be for people kind of comparable 5:29 Speaker 0: to an antidepressant 5:32 Speaker 0: in many ways. So let's tap on that a little bit. Let's tap on that because antidepressants are huge, 5:38 Speaker 0: especially in The United States. Many Yes, people are they on are. So let's dig into that. That's why I wanted to start with Tesofensine. So tell us a little bit, like, always a little bit about what it is, who should take it. So some and and and I guess us too sitting across from the table, like, we have different, 5:52 Speaker 1: very different personal experiences with this. Yeah. 5:55 Speaker 1: I thoroughly enjoy Tesofensine and he hates it. So it all depends on your brain chemistry. So there are basically Tesofensine, if we wanna make this really simple, it's a triple monoamine reuptake inhibitor. 6:07 Speaker 1: Those triple, okay, so it is going to basically increase your serotonin, 6:11 Speaker 1: your dopamine, your norepinephrine, 6:14 Speaker 1: those 3 big neurotransmitters. Mood, motivation. 6:16 Speaker 1: Serotonin is your happy but calming neurotransmitter. 6:20 Speaker 1: Dopamine is happy but 6:23 Speaker 1: little bit of energy, and norepinephrine is happy and excited 6:27 Speaker 1: neurotransmitter. 6:27 Speaker 1: So those 3 are being and Zoloft 6:31 Speaker 1: is a SSRI, serotonin reuptake inhibitor. Naltrexone and Wellbutrin are dopamine reuptake inhibitors. 6:38 Speaker 1: And norepinephrine 6:40 Speaker 1: just alone isn't very common, and I don't really know a 6:45 Speaker 1: brand name for that because it's not really a common thing for people just to take a single amount of. But these are not these are actually more than just those 3 put together. Right? If you just got those 3 from the pharmacy and took them all together, right, Tesofensine would actually work better and be 7:02 Speaker 1: more of 7:03 Speaker 1: of how your brain naturally reuptakes 7:07 Speaker 1: well, inhibits the reuptake, which is basically the wasting of of those 3 neurotransmitters. 7:13 Speaker 1: So it's actually better than just taking those 3 combined. 7:16 Speaker 1: It's a little bit stronger than than taking those 3 combined. But bay but what that's gonna do, yeah, you I wouldn't take it at nighttime because it's gonna give you energy. You might not be able to sleep very well. Yeah. 7:28 Speaker 1: You will be happier. You'll be yeah. It'll make you well, I'll speak for myself because he didn't have this this. But in general, the point is to 7:38 Speaker 1: make you make you happier, make you more content, 7:42 Speaker 1: not give you anxiety, 7:43 Speaker 1: although because of the serotonin, it helps with the anti anxiety. Those people who are very prone to anxiety, it might give you some it might activate some anxiety. 7:54 Speaker 1: They And- call it the happy drug. They call it the happy And why it is why are we talking about it, right, in the realm of, like, supplements and fitness? 8:02 Speaker 1: Because 8:03 Speaker 1: it is used as a appetite suppressant. 8:06 Speaker 1: Why? And unlike some of the GLPs that physiologically, 8:09 Speaker 1: you know, they work, 8:11 Speaker 1: in your body, this is all about your brain. So essentially, it is making your your brain just content. 8:18 Speaker 1: Alright? So you are not looking for any dopamine spikes from food. Yeah. Right? That's kind of a huge reason why a lot of people eat and especially eat sweets- Yeah, emotional. Is because and whether we know it or not, right, we tend to we want that sweet and bam, my brain feels good. This literally will make food and seeds not be as good, but it also makes you feel Because you're satiated. I'm satiated. My brain is satiated and I'm not looking for any extra happiness spikes. 8:47 Speaker 1: It's this is why, 8:49 Speaker 1: I don't know, I mean, my dad tried to quit smoking and was taking Wellbutrin 8:53 Speaker 1: to quit smoking. 8:55 Speaker 1: Naltrexone 8:56 Speaker 1: is a thing in 8:57 Speaker 1: the treatment 8:59 Speaker 1: business that helps with cravings. Okay? And that does well dopamine reuptake inhibitors. And why? Because it makes your brain feel content. You're not looking for that thing to satiate a craving. 9:09 Speaker 0: Which is interesting. Let's sit on that for a 2nd because I 9:12 Speaker 0: think 1 of the biggest struggles that most people have, especially probably in The United States, 9:17 Speaker 0: is cravings. 9:18 Speaker 0: We've both worked with numerous people in regards to diets and exercise and stuff like that. 1 of the biggest things that I was up against with people were men that I was working with was sugar, 9:28 Speaker 0: sugar cravings alone. You know, not let's talk, not even talk about the addiction of like other drugs and alcohol and stuff, but just sugar is 1 of the worst drugs. 9:36 Speaker 1: And it's been I've talked with a lot of people that take it in that it changes the cravings to that stuff. That's pretty powerful. It's really powerful. You know I mean? That, it changes the cravings. Right? You don't they don't you will be on it and go, this ice cream is just not doing it for me. It just does not taste as good, and it's because your brain just doesn't care for it anymore. So similar to GLP-three. 9:58 Speaker 1: Yes. Yeah. Right. It has some of those similar, 10:01 Speaker 1: yes, 10:02 Speaker 1: brain effect, new new nootropic effects as GLP-three. Also, you know, it's an interesting thing. So those people who so men, if you or men and women, if you, 10:12 Speaker 1: if you want your sex if your sex drive is lacking a little bit and you're the person who eats 10:17 Speaker 1: sweets at night before they go to bed, cut out the sweets and watch your sex drive increase. 10:23 Speaker 1: Because you are choosing sweet to get to get that 10:26 Speaker 1: spike of happiness. Right? And and that's easy. That's just you comfortable. 10:30 Speaker 1: You comfortable by yourself. Oh, no. I've got have Twinkies are sex. Twinkies are sex. Right. I mean, if you have a significant other that you're there next to, try cutting out the sweets and your body will be looking for some other way to be happy. Alright. Let's talk about that for a 2nd. So would you say so sweets, would that what would would, like, 10:47 Speaker 0: you know, God sweets do the same thing, meaning, like fructose or like, fruit? 10:53 Speaker 1: Yes. 10:53 Speaker 0: Kind of similar. Mean, it kind of probably is the same. So don't eat fruit before you before you go. You're looking to get some love? Yeah. Yeah. Don't eat some fruit? Yep. Eat a steak? Eat a steak. 11:02 Speaker 1: Absolutely. I would really say that. Also, if you try to burn any fat, 11:06 Speaker 1: or work on your physique, don't eat fruit. We understand everybody's like, hey. Fruit fruit is healthy. Okay? Now fruit is healthy because it has good vitamins and minerals, but 11:16 Speaker 1: a banana is the same thing as eating a Snickers bar when it comes to your physique wise. Right? They're both sugar. Okay. If you eat them before you go to bed, you're not gonna burn that sugar off. And that sugar is now going to since you don't use it, it's gonna go, well, shoot, this is perfect storage 11:33 Speaker 1: calories, and I'll just convert this to fat and keep it on me in case I eat it and I'm starving or or cold later 11:41 Speaker 1: later on down the road. So fruit should be eaten, 11:44 Speaker 1: in the morning when you get those vitamins, minerals, and you get to burn use the energy that's providing you. 11:50 Speaker 1: I'm gonna say a lot of people don't fruit. Here's another 1. Fruit. Don't eat a full meal and then eat fruit on top. You will be gassy because all of that food needs to the fruit goes in there in this hot, 12:02 Speaker 1: in this hot, unvented 12:04 Speaker 1: climate while your food is digesting, and this fruit is going to ferment 12:09 Speaker 0: before it gets digested Yeah. And will cause gas in your stomach. Yeah, so on the carnivore or like a ketogenic diet, and you know, that would just, man, in some of my comments when I'd post certain things in about fruit, man, you wanna get some people mad talking 12:24 Speaker 0: about how the fruit's not as healthy as you thought it was healthy, Especially today's fruit, probably. It's like And they're not getting organic. It's just I Alyssa gave Jack some apple the other day. He's like, it doesn't taste like anything, and I took a bite of it. I'm like, it doesn't. Like, what the hell? What the hell, bro? Just the fruit sucks. Man, if it's not organic, it's Have you heard about those apples that are flavored, 12:45 Speaker 1: like pink lemonade? 12:47 Speaker 1: Brandy brought some in the other day. Actually really did it really. And it was pink. Once you bit into it, it was pink. 12:53 Speaker 1: But talk about more genetically engineered fruit. 12:57 Speaker 1: Real bananas don't look like that, by the way. No time in history has a real banana ever grown like that large. 13:05 Speaker 1: They really look to they're about this big and are not all the same perfect shape either. 13:11 Speaker 1: Yeah, but I guess fruit isn't Fruit is good for you. It carries all these vitamins and minerals. Again, antioxidant properties, certain fruits are better, right? But as far as I'm talking about 13:20 Speaker 1: losing weight, maintaining physique, there's a good there's a right time to eat them and the right time not to. And it still is sugar. 13:27 Speaker 0: So in regards to Tesofensine, 13:29 Speaker 0: some of the stuff that we've read and we have a lot of people that have taken it, you've taken it, you can kind of see if you agree with this, but it's gonna improve your mood, clarity of thought, 13:39 Speaker 0: and 13:40 Speaker 0: it's been known or studied for to help make better decision making in 13:46 Speaker 0: that part of your brain. Isn't that crazy? That's interesting. That is interesting. 13:50 Speaker 0: Because of your focus. 13:52 Speaker 0: So if you're somebody that's not disciplined, it helps a little bit with some of the discipline. I mean, you still have to always eat right and exercise if you want certain things to happen well, but it 14:03 Speaker 0: kind of helps to get the ball spinning downhill is a better way to say that. Mean, is it's 14:08 Speaker 1: very helpful for delaying gratification because, again, you're not looking for gratification. 14:12 Speaker 1: Yeah. You know what I mean? You're just not looking for those spikes 14:16 Speaker 1: of artificial 14:17 Speaker 1: happiness 14:18 Speaker 1: that are all around us at all times. Yeah. Because you're already pretty discontent with yourself, right, which is like the ultimate 14:27 Speaker 1: spiritual 14:27 Speaker 1: experience to be, you know, is, 14:30 Speaker 1: right. Just to be completely happy with yourself and not need anything, 14:35 Speaker 1: and then you make damn good decisions, damn good at all times. So not only is your brain gonna be clearer and more awake I mean, 1 1 thing I noticed, I don't know if you knew me, 14:46 Speaker 1: like, I guess there maybe there were changes in my life, but I used to like to take naps. 14:52 Speaker 1: And I look back, and now I've taken started to take Tosapiensin. Now other things in my life have changed also, but 14:58 Speaker 1: napping, even if I'm dead tired, is the last thing that's on my mind. Interesting. Even if I get sleepy Are you taking it now? I am taking it now. Because you don't feel like taking Nathione too. No. Most people. No, I don't. That's good. No, still, if I eat some food, if I eat a big, like- Carb loaded. Yeah. Carb loaded meal, like I will fall asleep. And I mean, believe me, I could fall asleep at any 2nd during the day. Give me 5 minutes sitting up in a chair. I could fall asleep, but I don't want to because 15:22 Speaker 1: I would rather live 15:24 Speaker 1: life. 15:25 Speaker 0: Yeah. You have success with me. I 15:28 Speaker 1: think I would rather sleep because there was probably a slight bit of depression, 15:32 Speaker 1: and I think that the Tesofensine is taking care of that. Well, that's some of the point of it. That is kind of the clinical- There's so many people taking antidepressants. 15:41 Speaker 0: I mean, 15:43 Speaker 0: gosh, almost most people, but a lot of people. It's so freaking common. 15:48 Speaker 0: So I'll give you my experience. So Will's given his experience and I would say most people I talk to have similar. I've had so many people, it just makes me happy. It just makes me happy. My experience is different. So when 15:59 Speaker 0: we, went to Cancun with my family, 16:03 Speaker 0: for my cousin's wedding, blah, blah, blah, and I just started taking it because it read well. I was studying it and it read well, I'm like, sounds pretty cool. And so I started taking it and I did not have that experience. I was in Cancun and 16:17 Speaker 0: felt off. I felt just 16:19 Speaker 0: lack of focus, kind of cloudy headed, just like I hadn't had my V 8. And I was starting to go, 16:26 Speaker 0: Why do I feel like this? It almost was the opposite of affection because I felt lack of motivation, which I'm always motivated to go to the gym. I was like, I had to make myself. And I start peeling back things, what I've taken, what I've changed, and I'm like, Is it the Tesofensine? 16:41 Speaker 0: Not thinking it would be that because it read so well. So 3 days into it, I pulled that out and literally within a day I was back to normal. So the point of that is very, again, 16:53 Speaker 0: we are so radically different and most people have that experience, but you know, I've always been a little bit wired different. Like, if I, you know, when I said to blow, I would not be so talkative, I'd be kind of quiet. You know? So it's kind of like the opposite. If I take Nyquil, I can't go to sleep. Okay. Stuff like that. So kind of maybe a- 17:11 Speaker 1: Which is common, I guess, it's just common people who like upper I mean, this is what I mean, for people who actually have ADHD 17:18 Speaker 1: Mhmm. You know, 17:19 Speaker 1: Ritalin and Ritalin and and Adderall finally 17:24 Speaker 1: calm them down. Yeah. And make their brains, like, be able to focus because it's not just like gears, 17:29 Speaker 1: you know, you'd see this is my visual on those. 17:32 Speaker 1: Think about gears, like, kinda working, fitting together, and then they start going a little bit faster, then the then then the nut, ping, spins off. They just start going out of control, spinning. Right? That's what 17:44 Speaker 1: I felt like on when I just take straight up uppers. 17:47 Speaker 1: Too much. Just too much. Brain spinning. So anyway, that's what kinda it slows slows a person with ADHD. Maybe you have a little bit of that 17:56 Speaker 1: Maybe you'll have a little bit of that in you. But the point there is his brain chemistry is different. 18:03 Speaker 1: Right? Like, everybody's brain chemistry is different. Well, it's like- You probably had an end, which I guess is a good segue into side effects 18:11 Speaker 1: what not to do. Dangerous. So because this is a triple reuptake inhibitor, 18:17 Speaker 1: the warning is people, I 18:21 Speaker 1: wouldn't take any if you are taking an antidepressant. Right? If you're taking SSRI or 18:27 Speaker 1: SNRI, 18:29 Speaker 1: I wouldn't 18:30 Speaker 1: take those and take desofensine 18:32 Speaker 1: because you're just doubling up on that. There such thing as, like, serotonin sickness. And my guess is that you probably have a ton of serotonin, and it and it just overloaded you. 18:43 Speaker 0: Something was off. 18:45 Speaker 0: And so it's not for everybody. Yeah. Think you were telling me kinda recently. 18:49 Speaker 0: So we were thinking about doing Tesofensine a few weeks back, and I think you were saying that we were talking about it in my experience with it. And I think you were saying, bet you if you kinda let it kinda ride a little bit, would ironed out. Yeah. You know? Or started lower. 19:01 Speaker 1: Yeah. Started lower and then kinda worked your way up. 19:04 Speaker 1: Speaking of dosing, I would say that 500 micrograms, 19:07 Speaker 1: that's what I take a day. But I would say about, you know, maybe those who think they're sensitive to things, 2 50 micrograms a day to start. 19:16 Speaker 1: Taking the 1st 0.5 of the day, again, so if take it at night, it may make you not sleep. But the range, 250 micrograms to 1000 micrograms. 19:25 Speaker 1: K? I have taken 1000 micrograms, 19:28 Speaker 0: which for what I have is 2 pills, and I'm fine. I just have a little extra energy. I just feel like I just don't need that that much, and 500 is good for me. Interesting. Well, it's funny because the way that you're explaining this is how I feel on Modafinil. 19:42 Speaker 1: Okay. 19:43 Speaker 1: Because you know I love Modafinil, but do you feel like that on Modafinil? I get too that is too much for me. Like, I can't I don't like taking more than a full I mean, more than 0.5 a pill. Oh, wow. Yeah. Oh, man. I've taken 2. Yeah. So that is the difference in our brain chemistry. 19:59 Speaker 0: Yeah. Like to be I took a midafinil before this. I take it every time I would do a podcast because I feel razor focused. Yeah. 20:05 Speaker 1: And for me, if I took a if I took a full midafinil 20:08 Speaker 1: on a pretty empty stomach, right, and maybe drink some coffee, I would feel like kind of cracked out. Oh, wow. That's just true. And like as you do, when you take too much stimulant, 20:18 Speaker 1: I would get kind of her kind of jittery and almost hypertensive and withdrawn 20:22 Speaker 1: because I don't feel good. Yeah. You know? There's always trap, bro. Everybody's different, man. Everybody is different. 20:28 Speaker 0: It's just tough. So it's like so when you hear some dude on TikTok saying that you should do this, you should do that, and, 20:33 Speaker 0: just do the damn research. Not really the research. Do are doing the research. Like, we've tried it. We we, 20:39 Speaker 0: we try it. We study it. We try it. We talk to a lot of people. And the research is is yourself. 20:45 Speaker 1: Because you're not gonna get the same effect. Always just established it. Yeah. Absolutely. And if you just read on a piece of paper, 20:52 Speaker 1: well, cool. That's what it 20:54 Speaker 1: might do or that's supposed to do, but who knows until you actually try it. 20:59 Speaker 1: You're all a science project. So there you go. I'm a fan of I'm a fan of it. I've said the Most are. Most people love it. And but, again, I guess I have taken antidepressants in my life. Every 21:10 Speaker 1: rehab I went to, 21:12 Speaker 1: I remember I would 21:14 Speaker 1: be in rehab, I'd get off drugs and be like, Man, am I depressed. Oh, really? Duh. I always felt great when I finally got off drugs. Yeah, I 21:20 Speaker 1: would feel great. 21:22 Speaker 1: But as I turned life, 21:25 Speaker 1: would get definite bouts of depression for sure. 21:28 Speaker 1: And so they would put me on antidepressants 21:30 Speaker 1: and then of course, you I would just stay on them. Yeah, you're holding off. Ultimately, I got off, you know, especially like serotonin Zoloft. 21:39 Speaker 1: Yeah. The worst part of that is like the brain zaps. Well, the worst part of that 21:43 Speaker 1: is just not being able to be happy. Right? When you're getting off of it, you do go through a week period of like, damn, dude, I'm not happy. So you do wanna wean yourself off. But 1 of the noticeable side effects is brain disaster. Your brain kind of just go like 21:57 Speaker 1: you can be, let's say if you're walking down the stairs, you might just lose track of 0.5 of that step you took and good thing there wasn't an obstacle you need to 22:04 Speaker 1: avoid really fast because it wasn't gonna happen. Off that stuff? Holy crap. That sounds scary. No. Frankly, 22:10 Speaker 1: somebody like me, I don't really mind them. I think they're kind of fun. But 22:14 Speaker 1: my girlfriend was looking at it and was like, oh my god, this look at this girl on TikTok or whatever. She she's like, The brain zaps are the worst side effect. And I was like, Oh my God, she's never actually withdrawn from 22:25 Speaker 1: anything real, Yeah. Brain zaps are nothing. Hell, 22:29 Speaker 0: can even induce them. 22:31 Speaker 0: Which I would do. Because I've never come off Xanax, I've seen some people look at Xanax. Is gnarly. That's another 1 that just is I was never into Xanax. There was 1 drug that I wasn't 22:41 Speaker 1: into. I mean, I hate Opiates win. 22:43 Speaker 1: Opiates is the most miserable thing in the world. Although you cannot die from that withdrawal. Alcohol. Whereas alcohol and and See, someone come off alcohol, shakes Oh, will it's bruise. Those ones you die. Yeah. Because of seizures. 22:55 Speaker 1: Crazy, man. So don't do drugs. Well, there you go. Tisofensine. 23:00 Speaker 0: Most people like it. I do not, but it doesn't matter. You should try it for you if you're somebody that, you know, most people I will tell you straight up, they're like, It just makes me feel happy. Yep, 23:10 Speaker 1: happy 23:12 Speaker 1: being a drug. You know, it's not like this super euphoric like, oh, yes, I'm high. 23:20 Speaker 1: It's not like that. Right? You don't and I don't find it 23:23 Speaker 1: addictive. Now now, again, like I just said, it's coming off of serotonin, 23:29 Speaker 1: coming off of like an SSRI 23:31 Speaker 1: can pose some problems. Now, Tesofensine 23:34 Speaker 1: will has the capability of doing the same thing. So 23:38 Speaker 1: I would say it's either something you wanna do and just stick with. 23:43 Speaker 1: Although, just for example, like, I've just spent the last 5 days 23:46 Speaker 1: not doing it because I forgot. Mhmm. And I definitely didn't have 23:52 Speaker 1: any of the withdrawal symptoms that I would have coming off serotonin. 23:55 Speaker 1: But theoretically, 23:57 Speaker 1: you should have to have some withdrawal symptoms. 24:01 Speaker 1: So long as you take Yeah. Longer you take it and the higher dose you take, right, the more potential withdrawal symptoms you have. 24:09 Speaker 0: Right, let's jump into Methylene Blue, which we 24:14 Speaker 0: took a little while before us to come around to it. I didn't really study it because, you know, when you and I 1st started talking about it, you had said some things that you had dug into it, so we ended up not 24:25 Speaker 0: getting it. 24:27 Speaker 0: But now we have decided to. I just started taking it about a week ago, I can give that experience, but it's been my 1st time taking it. Tell us a little bit about what it is and why we who take who should take it? Yeah. Methylene Blue is 24:38 Speaker 1: Methylene Blue is the thing that is it's a dye. Right? Still used in, like, modern science today 24:45 Speaker 1: to dye like microbes. So look in the microscope so you could see things better. 24:49 Speaker 1: But and it was 1 of the it's shoot. It's 1 of the 1st drugs drugs, like, ever ever made back in the 18 hundreds, and actually was used as, a malaria 24:58 Speaker 1: medication. 24:59 Speaker 1: But 25:01 Speaker 1: it's 25:03 Speaker 1: who should take it? Like, it is being used right now for, like, in clinical settings for 25:10 Speaker 1: oxygen, 25:12 Speaker 1: to help oxygen travel throughout somebody's blood. There's rare conditions where 25:16 Speaker 1: oxygen, 25:17 Speaker 1: even though blood is flowing just fine, oxygen isn't flowing. Okay? 25:21 Speaker 1: And so it's been used in hospitals for that. It's also being used kind of off label 25:28 Speaker 1: in emergency 25:29 Speaker 1: medicine for patients with going into shock, where their blood pressure is lowering. 25:35 Speaker 1: It does the opposite of any pump 25:37 Speaker 1: drug, right? So 25:39 Speaker 1: any pump drug that you take is a vasodilator, 25:42 Speaker 1: opens up your blood vessels, right? This is going to restrict your blood vessels, therefore making your blood pressure higher. So those people who are in shock and blood pressure is lowering and is going to very, very dangerous levels and it's too low, 25:57 Speaker 1: it's gonna kind of close-up your veins and cause more pressure in your blood. So blood is gonna flow, I don't know, the veins will be more rigid and blood pressure will rise to healthy levels. 26:08 Speaker 1: So the takeaway there is if you're trying to get a huge pump at the gym, Won't work. Probably not the best thing to take. Yeah. Right. Now it is is gonna help with oxygen and blood. K? So oxygen 26:19 Speaker 1: is the lifeblood of of of blood. Right? Like, that is what the hyperbaric chamber does. Yeah. It is basically the same you like, you take Methylene Blue if you're a athlete 26:29 Speaker 1: training 26:30 Speaker 1: for the same reasons that you would train do high elevation training. Right? Or hyperbaric 26:36 Speaker 1: chamber training because it's going to oxygenate your blood, which in turn gives you better performance, 26:44 Speaker 1: stamina, 26:45 Speaker 1: muscular stamina. But also, so there's the physical 26:49 Speaker 1: benefits. But also it is 26:52 Speaker 1: pretty similar to Tesofensine where it's gonna affect those 3 neurotransmitters also. K? So it is a nootropic 26:57 Speaker 1: as well. Brain function. And it's gonna help your brain function. Mood, it's gonna it's gonna work on those 3 neurotransmitters 27:03 Speaker 0: also. Helps, like, stabilize emotions is what I read. That's interesting. So if you have a so, man, if you have a sensitive 27:10 Speaker 0: bride, maybe give her some Methylene Blue. Just joking. Joking. Don't 27:15 Speaker 1: put it in your pee. The problem is, yeah, she's gonna know. 27:18 Speaker 1: You just took it and, 27:20 Speaker 1: your pee was blue. I never I've never seen anything like it. That can be an alarming side effect, folks, but that's Like, real blue. It's okay. That's normal. Your tongue, you see them a lot. Like, they're usually in pills. Well, shit pills, liquid, or troches, which is like sublingual 27:37 Speaker 1: tab. Yeah. 27:39 Speaker 1: It's pretty clear who's taking them if they open their mouth and stick their tongue out because it will be blue. Yeah. That's normal. That's okay. But, yes, mental clarity, 27:47 Speaker 1: those of us getting older, it's right, some neuroprotective. 27:50 Speaker 1: Yeah. Those who are losing, yeah, losing memory, you know, I forget simple words sometimes. 27:56 Speaker 0: You're right? How 27:58 Speaker 0: do you spell the the the 28:00 Speaker 0: getting old such, man? 1 of my favorite quotes is, youth is wasted on the wrong people. 28:05 Speaker 1: Yeah, 28:06 Speaker 0: that's true. Yeah, I so I started, what I was starting to read about, because we didn't have it for a long time, then so many people were asking for it. Yeah, you know? And so I, yeah, I hadn't studied it because you and I had talked about it for bit. So I started digging into it. That was why I wanted to try it just because as you get older, our brain, our mitochondria starts to obviously 28:22 Speaker 0: not work as well. So it helps it be more efficient in regards to just getting old. It's good to boost, like it has antioxidant 28:30 Speaker 0: properties. So like in regards to like, 28:33 Speaker 0: you know, what antioxidants 28:36 Speaker 0: do is going to get rid of like free radicals, like toxins. I mean, we breathe in just crap. Yes, you know. Like just eat crap. 28:44 Speaker 0: So it's gonna help with that type of stuff. So that's kind of why I started to take it. Yep. I'm feeling older. Brain feels a little bit slower. 28:52 Speaker 1: I hear you. 28:54 Speaker 0: I'll let you damage that we have both done to our brains. Yeah. My memory sucks, dude. Yeah. Was yours? Yeah. Mine's bad. It's good. My 29:02 Speaker 1: short term memory sucks. My long term memory is pretty good. 29:06 Speaker 1: You know? I don't know. It's like the recollection of words is the that's the main thing that kills me sometimes. Yeah. But, like, I can learn processes still very good, you know, and retain all of that memory, but I absolutely forget simple things. Yeah. Like, yes, like words, just things right in front of me. What is this thing called? 29:25 Speaker 0: Table. Camera. 29:27 Speaker 1: Like, you know? 29:29 Speaker 1: Yeah. It it also so another thing, it will it will help regenerate 29:33 Speaker 1: other antioxidants. 29:36 Speaker 1: So like your natural, like NAD levels, glutathione. 29:39 Speaker 1: So basically it will boost your NAD levels and 29:43 Speaker 1: glutathione. 29:44 Speaker 1: So take those and they will be, 29:47 Speaker 1: yes, 29:48 Speaker 0: hyper- Boosting glutathione. Boost it. Needed. 29:50 Speaker 1: Yes, everybody should be taking Glutathione. 29:53 Speaker 1: When I got my blood work done, my Glutathione levels were low. I was like, Dude, he's like, Yeah, that was weird, right? Yeah, that was weird. So I don't know. Yeah. That's why we get our blood work That's why you get blood work done. You have somebody like Doctor. Scott who tells you why. Deep dives into So, 30:09 Speaker 1: Methylene Blue again, I guess here's the concern, folks. The same thing that the concern is with Tesofensine. 30:15 Speaker 1: I would, and frankly, 30:16 Speaker 1: I would 30:18 Speaker 1: be reminiscent if I didn't say, Hey, don't take Methylene Blue and Tesofensine together. 30:23 Speaker 1: Don't do it. Okay? Also, just the same reason we don't wanna take either of those and any of those 3 antidepressants, 30:29 Speaker 1: especially 30:30 Speaker 1: SSRIs. 30:32 Speaker 1: K? That seems to be the serotonin sickness seems to be the biggest worry, 30:37 Speaker 1: not so much like a dopamine or norepinephrine 30:41 Speaker 1: overdose. 30:42 Speaker 1: You know? 30:43 Speaker 1: The signs of the serotonin sickness is is like kind of hypertension, anxiety, nausea, diarrhea. 30:52 Speaker 1: So that's what a person's gonna feel if you've accidentally taken too much serotonin. 30:56 Speaker 1: But, yeah, to be safe, I wouldn't take them together. This is an eitheror thing, and you for sure could and probably should cycle between them. Right? If we wanna talk about not building tolerance 31:06 Speaker 1: Right. Or 31:07 Speaker 0: Yeah. I think that'd a perfect scenario. Month on, month off. It's weird. Was thinking as we're talking, I didn't even think about that, but I have not felt the hated Tesofensine. I I haven't I can't say that I dig Bethany Blue or I hate it. I just started taking about a week. But I mean, I felt Tesofensine immediately. 31:25 Speaker 1: Tesofensine is pretty I think it's going to be Tesofensine 31:27 Speaker 1: is going to be the stronger 1 on the neurotransmitters. Yeah. In fact, like, it is a because it's up there where you with, like, the, like, appetite suppression. Yeah. It's up there. 31:37 Speaker 1: So looking at, 31:39 Speaker 1: I actually read some studies and looking at the comparison chart of, like, clinical trials between 31:45 Speaker 1: GLP-1s, 31:46 Speaker 1: so semaglutide, 31:47 Speaker 1: what was it? Was semaglutide 31:49 Speaker 1: versus Semaglutide. Tirzepatide 31:51 Speaker 1: versus phentermine, which is Phen Phen, which is basically it's an amphetamine stimulant to 31:58 Speaker 1: curb appetite. 31:59 Speaker 1: And 32:00 Speaker 1: patients 32:01 Speaker 1: lost 32:02 Speaker 1: 10% 32:04 Speaker 1: on 32:05 Speaker 1: Tesofensine 32:06 Speaker 1: and 32:07 Speaker 1: 13% 32:08 Speaker 1: semaglutide, 32:10 Speaker 1: percent on Tirzepatide. 32:11 Speaker 1: I think it was 3% 32:13 Speaker 1: of PhenFen. 32:14 Speaker 0: Which is kind of interesting, like, because the semaglutide 32:17 Speaker 0: is, 32:19 Speaker 0: gosh, I mean, so many people lost so much weight on it because they didn't eat at all. Yeah. So it's kind of interesting that it's only 12 or 13%. I know. Gosh, it's such a bad drug. That's the only peptide that sucks. It does suck. It does suck. I wouldn't take that, everybody. Don't take that. 32:33 Speaker 1: Yeah. Yeah. Because there's just so much side effects. You just feel like shit. Like, great. I mean, when it 1st came out, I'm like, okay, so you got, so there's a drug that just makes you so nauseous and sick. Yeah. And that's why you lose weight. Well, shit, I could have done that. I mean, I could have figured out something Right? Like 32:48 Speaker 1: There's lot of people that Trick started something maybe. You just poison yourself another way. You won't eat any food also. 32:54 Speaker 0: That's why they- Although it won't kill you. Semaglutide 32:58 Speaker 0: has wounded people to the degree that got 33:00 Speaker 0: so sick on it that they weren't even willing to try tirzepatide, 33:04 Speaker 0: let alone reticutide, which you're not even talking about the same sport. No. No, not at all. Just Not at sucks. And I like when I tell somebody about reticutide, 33:12 Speaker 1: it's I'd say, yes, it's in the GLP-one family, but like, let's just get that out of your brain. It's not like Semaglutide, right, because everybody has that negative connotation in their mouth. Have I ever told you about my Semaglutide experience? No. Not like I ever have. So 33:26 Speaker 0: it was when don't remember where, like, it was sometime this year and I was still doing a lot of the fitness content, blah, blah, blah, blah. And I wanted to throw out a 72 hour fast, which I'm great at them, but I was more in tune to work and I think it was my back was hurting, blah, blah, blah. I just needed some content. People love the 72 hour fast things. Mentally just wasn't there. I just wasn't ready to do it. And if you're not ready for a 72 hour fast, it's mental. 33:48 Speaker 0: And I could breeze through them usually, but my mind wasn't there. So I'm like, I'm gonna take some Semaglutide. Okay. Because it's just gonna shut my Yeah. It sucked, bro. I felt like I was gonna die. I fucking hated it. I was just like, 34:01 Speaker 0: Oh, I felt so bad. But you know what was cool about that experience is I got to experience it because I was never really gonna try it. 34:08 Speaker 0: This is, you know, this is what we've heard about it in like so many people. But it was interesting. 34:13 Speaker 0: It really held up to par what I hear, and it sucked. I felt like I was sick. Yes. Yeah. 34:19 Speaker 0: Well, don't 34:20 Speaker 0: take it. There's there's it's like you have a choice to drive drive a Pinto or a Lamborghini with Retatrutide as people are still driving a Pinto, and you literally can choose. Mhmm. Silly. Yeah. So for those, I guess, listening, like, I would say, you know, if the goal is 34:34 Speaker 1: naltrexone's 34:35 Speaker 1: another interesting 1 that we didn't that we just kind of glossed over. But 34:39 Speaker 1: people have been taking naltrexone 34:40 Speaker 1: in the treatment community is known to you take that if you're an opiate addict and it blocks 34:48 Speaker 1: your opiate receptors. But you can't get high. Cannot get high. 34:52 Speaker 1: I've had several treatments, 34:54 Speaker 1: like I've had, I won't get into like gory stories here, but right, I've had several like implants and no, I didn't get paid for them. Oh, of 35:00 Speaker 0: injecting that? Yeah, 35:02 Speaker 1: so they they take a big ass pill, and they cut you open, 35:06 Speaker 1: and then basically stuff 35:08 Speaker 1: it in you and then, yep, and then sew it back up. Similar to basically a pellet, except when they inject those pellets, the testosterone pellets. Right? They cut you off sew it in. Okay. So same thing, and it's a slow release. But the 1st time I did it, I was not ready to be done 35:23 Speaker 1: using drugs. 35:25 Speaker 1: So you wanna get high. I wanna get high. And I, can't do that. I bought every drug to try to get high, and it didn't work. In fact, it blocked it was crazy. It blocked all, 35:34 Speaker 1: just all of my fake happy receptors. So every drug did not work. Right? 35:40 Speaker 1: Yeah. Tried to do cocaine. It just felt like I was just coming down. It was like I had sort of no dos. You know? All the all the anxiety and energy and no euphoria. 35:50 Speaker 1: Ugh. So cut all the euphoria out, and, literally, I found, like, the only things I could do to be happy was drive fast, work out, 35:58 Speaker 1: have sex, 35:59 Speaker 1: and listen to loud music. Right? Those are the only things and I was at a point in my life where I was just 36:05 Speaker 1: you know, that's the only thing that mattered, just, I need happiness right now. You know? And, 36:11 Speaker 1: ultimately, I ended up, you know, pulling a box cutter out and and 36:15 Speaker 1: surgery ing me myself, 36:18 Speaker 1: so I could get out of me. But Things we do, man. Yeah. Drug addiction. Crazy things we do. Drug addiction. But people are using naltrexone for, 36:26 Speaker 1: for for appetite suppression. 36:28 Speaker 1: Unless appetite suppression, it's really for just no dopamine spike 36:33 Speaker 1: suppression. 36:34 Speaker 1: And if you happen to search for your dopamine spikes with food, 36:39 Speaker 1: that's why you take it. Boom. But 36:42 Speaker 1: those of you who maybe don't wanna take any of those GLP-1s, test fencing's a good start. 36:47 Speaker 0: Yeah, man. I mean, like you said, it's a it's been somebody I have I'm the only person that I've heard of that doesn't like it, but each is own. But here you go, man. Those are good. I think that 36:56 Speaker 0: we kinda dug into those good. Anything else you wanna add before we kinda 37:01 Speaker 1: No. Cut this off? 37:03 Speaker 1: I personally am not taking methylene blue because I am taking Tesofensine. 37:06 Speaker 1: But 37:07 Speaker 1: Have you ever been? You know what? We started this conversation about methylene blue of why we didn't 37:12 Speaker 1: originally try to pick it up. Mhmm. And because as I I did some research 37:17 Speaker 1: and heard some horror stories of people's, like, livers failing. And 37:25 Speaker 1: since then, 37:27 Speaker 1: I've 37:28 Speaker 1: read more research articles and saw thousands of people taking this and that not happening. 37:34 Speaker 1: So 37:35 Speaker 1: that could have been just bad PR or a 37:39 Speaker 1: fake article or whatever. 37:41 Speaker 1: You beloved. 37:42 Speaker 1: I don't know. I guess, I don't I don't even wanna say that that's a potential 37:46 Speaker 1: thing to happen because I don't I just don't know, folks. But that's why we had a little we that's why we we didn't do it at the beginning, but 37:54 Speaker 1: I know tons and tons of people who love it, take it all the time. 37:58 Speaker 1: And, 37:59 Speaker 1: I'm excited to 38:01 Speaker 1: I'm gonna very soon stop the Tesofensine and 38:04 Speaker 1: do the Methylene Blue. 38:06 Speaker 0: Okay. It's been a week. So, so far so good, man. So far so good. But give us some, feedback guys in regards to some other peptides. I know those 2 aren't peptides, but they're in the category of that. 38:18 Speaker 0: What do you want us to talk about? The next round we're gonna go obviously to the Q and A, but, we do 2 a week And, so give us some feedback on some ones you want us to dig into. We've done a lot of them, if not most. 38:30 Speaker 0: So we're gonna obviously circle back around for some, but, give us some feedback of what you want. Anything else before we jump ship? 38:38 Speaker 1: That's it. Alright. Yeah. Good weekend. Although, we will. I don't know when you watch this, but Monday. 38:43 Speaker 1: Okay. Have a great work week now. Take care, guys. Later.