Peptide of the Week: NAD+ & Tesofensine: Anti-Aging and Brain-Based Weight Loss Explained Peptide of the Week https://peptideoftheweekpod.com/episodes/peptide-of-the-week-nad-tesofensine-anti-aging-and-brain-based-weight-loss-expla/transcript We are not doctors. The content on this site is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Amounts, timing and cycle lengths below are reported as the named speaker described them. Nothing here is a protocol to follow. --- 0:00 Speaker 0: Push your limits, train with precision, see the results. At Equinox, 0:04 Speaker 0: that's high performance loathing. 0:06 Speaker 0: Everything you need to lock in and unlock your potential at Equinox. 0:10 Speaker 0: Start today at equinox.com. 0:16 Speaker 1: Ultra running shoes are all about space. 0:19 Speaker 1: The space to go further, 0:20 Speaker 1: to feel better, to do something you never thought possible. 0:24 Speaker 1: And this space starts with ultra fit. Unlike traditional running shoes, ultra fit gives toes more room to move naturally, 0:32 Speaker 1: so every step is strong, balanced, 0:34 Speaker 1: and comfortable. Whatever you're lacing up for, stay out there with Ultra. Shop now at ultrarunning.com. 0:41 Speaker 1: That's altrarunning.com. 0:54 Speaker 0: Welcome back to the pepatide of the week podcast. I'm your host JD Denham. 0:58 Speaker 0: Across the way my buddy William T Haas. Happy Friday. 0 Busy 1:04 Speaker 0: Friday. Like always, it's never not a busy Friday. We've been going through a lot, but, 1:09 Speaker 0: life's good. What's it? What else is new, dude? 1:12 Speaker 2: Your life. Okay. So 1:14 Speaker 2: my girlfriend 1:16 Speaker 2: and- 1:17 Speaker 2: Fiance? Fiance. Well, no, no, because I have not asked her for the request. I have, the ring is being made. 1:24 Speaker 2: So I'm waiting for that. It's been a while too. It's been a little, I should have it now. And then I've been thinking about like, we've gone to Hawaii every year for the last 3 years. 1:32 Speaker 2: And 1:33 Speaker 2: with her family, we went with my mom 1 time, me, my mom, her, 1:38 Speaker 2: River, the 9 year old. And he, so we had a blast. My mother actually is like a free spirit. So when we said, hey, can you like watch him for the day? And so what River wants to do is run around the little lazy thing and jump off the rocks where it says, do not jump off the rocks. Of course. And so Allie's always complaining at him. We leave my leave in with my mom 2:00 Speaker 2: and we come back. They come back 2 hours later and my mom has been like, okay, so I tested it out. 2:07 Speaker 2: The rocks are fine. 2:09 Speaker 2: I taught him how to do flips. So he's good. He's like, say he's doing the flips into the water off of the rocks. 2:16 Speaker 2: That's just literally how my mom always taught me. She's like, you don't, 2:20 Speaker 2: But she's like, completely, 2:21 Speaker 2: I don't obey rules unless they make sense. And that's what I was taught. That's how I was taught. Like Love that. You don't obey any rule 2:28 Speaker 2: if it doesn't make any sense. So see a trespassing sign? That just means it's probably a cool place to be. These people aren't using the the land. Like, because we just went camping for my whole punked everywhere. 2:39 Speaker 0: Yeah. She's such a good spirit. She's she's a good spirit. Her her vibe, she's got my my wife's vibe. It's just she just lights up a room. She does. She's a 2:48 Speaker 2: good human. She's negative. Nothing negative. Mm-mm. My father told me once, he's like, you know, you ever notice for all the faults and what I complain about your mother is 2:57 Speaker 2: try to remember. I still have never heard her say 1 bad thing about any person, about anything. 3:03 Speaker 2: Like she doesn't complain. She doesn't go, this is a stupid commercial. Yeah. Rare. And I thought about it, I'm like, God damn, that's pretty hard to literally 3:11 Speaker 2: not say anything bad about anybody 3:13 Speaker 2: at all. It's crazy. 3:16 Speaker 0: But yeah, right. It is kind of crazy, but like do, I get it. You know who I know that like that is, Scott, Doctor. Scott. 3:23 Speaker 0: I've 3:24 Speaker 2: known him most of my life. Never heard him say 1 negative thing about anybody. You're right. You're right. And in our conversations we've, I think we've had conversations where something like, Oh, this bad. And he doesn't like partake in that. Yeah. If he just goes, people talking shitty, he dips up. 3:38 Speaker 2: Okay. Good for him. So anyway, what's going on? I don't know where that came from, but yeah, my mom teaches him how to do the flips and Allie's like, oh, 3:47 Speaker 2: well. Anyway, 3:48 Speaker 2: he is now 3:50 Speaker 2: officially like enrolled in school, a block from our house. Sweet. Because she came from, like, RSM, Rancho Santa Margarita, which is 45 minutes away. So does his school, his, like, his private school. And, 4:02 Speaker 2: it's a pain in the ass. Like, it puts everybody in a bad mood. You gotta commute 45 minutes there and back. I can do it. Plus, it lowers the time at home to do homework and have fun. Right? So this is like sports home, homework bed. Right? That's no fun. And then it just raises everybody's stress levels. Plus 4:19 Speaker 2: I did this. I went to a private school in junior high and they gave us a 300 page packet of homework to do over the summer. 4:27 Speaker 0: What the 4:28 Speaker 2: he's a kid. Like, so the amount of homework that this 9 year old brings home every day is And 4:33 Speaker 2: I am all about, and I actually am all of like absolutely for 4:38 Speaker 2: academics 4:39 Speaker 2: and, 4:40 Speaker 2: school, 4:41 Speaker 2: but 4:42 Speaker 2: that's nuts. We should have let a kid be a kid more. Like, that's stupid. Yeah. 4:47 Speaker 2: So there's too much damn homework. So anyway, he will do a lot better. He'll, for the 1st time, have a community and like a neighborhood 4:53 Speaker 2: vibe, right? Like play sports with the kids he goes to school with, not just be a commuter. 4:58 Speaker 2: That's what I did in private school and I hated it until I finally got to go to a public school in high school. 5:04 Speaker 2: Yeah, it was a lot easier, but, 5:06 Speaker 2: but I got to do it. I got to, you know, play sports against people who are actually good and 5:10 Speaker 2: in this be back with the neighborhood and have a real sense of community. So that's exciting. Riding bikes, come home when the lights come on. Yeah. 5:18 Speaker 2: Those stories are legit. It was like, was like, that's what you can do. We got them actually a motor scooter just now. It's in my, it's in the office, hidden with a blanket over it. If he's dangerous, 5:28 Speaker 0: dude. Holy shit. Kids in my neighborhood, 5:32 Speaker 0: Those are cars, man. They don't know how to drive them and they're all over the road. I'm like, dude, I've always, like numerous times. Scare the crap. Yeah, it is crazy. 5:40 Speaker 2: It's a scooter at least. It's not an e bike. Okay. 5:43 Speaker 2: He, Albert, did no chance in hell getting in the e bike. He barely can ride a bike. He just learned how to ride a bike. Right. His dad never taught him how to ride a bike. He was he learned how to ride a bike about 3 months ago. 5:54 Speaker 2: I bought him a bike too 1 time to try to teach him and he didn't wanna do it. And I that night, I gave it to the poor kids down the street. 6:02 Speaker 0: Did he Oh, 6:05 Speaker 2: thank you. So the whole thing was proposing. 6:09 Speaker 2: I was thinking about doing the proposal in Hawaii, 6:12 Speaker 2: but then I don't really wanna wait 3 months after having the ring. 6:17 Speaker 2: It's we're not gonna do anything that's, like, extravagant. 6:20 Speaker 2: She did say just don't 6:22 Speaker 2: propose to me in a restaurant. 6:26 Speaker 2: At least she told you. Yeah. At least you don't. You probably would've. They probably would've. I've been like, well, it's a perfect way to do it. So she works in a restaurant too, so I think that's all she sees a lot. So I don't know. Maybe I'll wait till Hawaii, but that- 6:38 Speaker 0: don't know. Nobody's so different. Like, you know, Chad had a big like, I'm not, you know, and then like, I didn't have, I think I've told you this, but I didn't have people there to film and her family wanted me to. I'm like, not my style, man. I just wanted to propose. 6:50 Speaker 0: And I think I told you this, but, when I had proposed, I was nervous as hell. I knew she was gonna say yes, but I was still nervous. Got down on my knee, walking at a crystal cove. Nobody was around. Luckily 7:02 Speaker 0: a couple were kind of was trailing after I proposed to her and grabbed my phone and got some pictures and stuff because I was stoked that I actually had that because now we could relive that scene so to speak. And so 7:14 Speaker 0: I don't know if you at least have a budget. I'll do somewhere as well. Does it need to be professional? Yeah. You know? Yeah. Like, 7:21 Speaker 0: Amy, then I don't know if you saw Justin. Was there when he did that with his, fiance and we listened. I like went up and did the rose petals and hooked him up and duh, that was dope. It was romantic. 7:32 Speaker 0: I'm very simple. Yeah. Like just me and my chick, me and my wife, we're very simple. 7:37 Speaker 0: We did a huge wedding. I think it was more her family than like the usual. I would've like eloped just me and my girl, but you know, it's kind of depends on what they want. 7:47 Speaker 2: Luckily she does not want a big wedding. 7:50 Speaker 2: When I talked to her dad, her dad's like, you guys aren't going to be like dressed up in like tuxedos and shit. You? Mike Gunnar man. 7:57 Speaker 2: Cut off serious bro. Cause he thinks it's like, he's going to pay for it. No, that's not actually why 8:02 Speaker 2: Somebody had to announce. He's like, oh yeah, well, probably because he doesn't want to pay for it. I'm like, oh, that's a good thought. But no, I think that we will have a wedding where we will not be wearing shoes. 8:12 Speaker 0: Cool. 8:13 Speaker 2: So whatever that is, whatever that takes, that means it's just laid back and chill. And if it's gonna be a like we did think about destination wedding, right? But 8:21 Speaker 2: if we do that, I will be paying for everybody who's invited. I hate it 8:27 Speaker 2: that you invite you make a destination wedding 8:29 Speaker 2: and expect everybody to drop $5 on plane tickets and hotels for you. So I don't like that. So if we're going to do that, then I better invite not a lot of people. I don't 8:40 Speaker 2: End up spending $300,000 8:42 Speaker 0: on a wedding. Yeah. I mean, I 1st wedding, was 8:46 Speaker 0: We were early 8:47 Speaker 0: 20s and had no money. We did 40, it was 40 the city of, 8:52 Speaker 0: what was it? 8:54 Speaker 0: Laguna, I think it was over the cliffs. Gorgeous. It looks Have you been to cliffs there? It looks like Hawaii. I mean, it's absolutely gorgeous there. And, the city 9:05 Speaker 2: literally comes and counts. You can have 40 people, which was great. We were broken. Was just immediate family and it was dope. Well, I think that literally showed me an article and I think that they're banning weddings now. Really? And 1 of the big sites there, there was like a big protest group. That's the, 9:21 Speaker 2: they are, they're protesting 9:23 Speaker 2: all of the flower petals 9:25 Speaker 2: are, 9:26 Speaker 2: damaging 9:27 Speaker 2: the ocean and the sand. Oh man. 9:30 Speaker 0: The world we live in. 9:32 Speaker 2: And I am actually a good environmentalist. 9:34 Speaker 2: Like I do believe in the environment. That's crazy. 9:39 Speaker 0: I'm gonna get back to your mom on just that way of thinking, because that's right. I'm gonna teach my sons to do that. Like if that rule steps outside of your integrity, 9:47 Speaker 0: don't fault. Don't fault. It's a little punk rocky, but you know I mean? But it means you need to have a good head on your shoulders and be able to interpret roles right. But verify. 9:57 Speaker 0: People are full of shit. But 10:00 Speaker 0: yeah, so my son, 10:01 Speaker 0: 2 today, my little chunker. Oh, that's right. Oh man. It's 10:05 Speaker 0: crazy how 10:07 Speaker 0: I have 3 kids and 2 granddaughters. I just had a granddaughter 2 days ago. So lot of life going on in my family. 10:14 Speaker 0: But my son's radically different. My son Mason is the 1st brown haired kid that I had. I've had 2 toe heads 10:21 Speaker 0: and he came out of the womb just hungry. And Jack's is just for the athletic and Mason just loves to eat, dude. That kid loves to eat, but he's also my little lover, dude. He's just, 10:32 Speaker 0: cuddle up on me. So we get to celebrate him this weekend. My wife, you know, does she 10:39 Speaker 0: is the party planner extraordinaire. 10:41 Speaker 0: I don't look at all the things that she buys because I'm like, you must be rich. Like 10:48 Speaker 0: she gets 10:50 Speaker 0: balloon man, a face painter. I could go on and on. I'm like, in the world he's 2? But 10:55 Speaker 0: anyway, she likes to do that. Do you need those 10:58 Speaker 2: outdoor heaters back? 11:00 Speaker 0: Think it's supposed to rain a little bit on Sunday, which she's all bummed, but it is what it is. Do you still does she have 1 of those, like, is she getting the blow up pools? Of course. Okay. Good. Who cares? The kids will just who cares? If it rains on them, they're fine. It's their kids, man. It'll be fun. It'll be, we haven't had people over in quite some time, so that will be cool, but, that's the good stuff. 11:20 Speaker 2: Got an awesome backyard for it too. Yeah. Yeah. Yeah. He's got just this 11:25 Speaker 2: big old backyard with fire pit built into the middle of the yard 11:29 Speaker 2: and Orange 11:31 Speaker 2: County. Then a cliff on the other side where there's a big park canyon park where I used to walk my dog. I would walk my dog and like throw pine cones up there at Brett's house. 11:40 Speaker 2: I'd be like, Hey, did you ever have pine cones just lobbed in your yard? You ever noticed that? I 11:45 Speaker 0: was on the phone with Brett 1 time when it was super windy on the phone, literally Brett. 11:49 Speaker 0: And he's like, man, 11:51 Speaker 0: it is so windy. I'm like, and I 11:54 Speaker 0: was talking to him. He said, dude, my neighbor has a trampoline in their tree. And how ironic was I was looking at my office goes, looks outside to the backyard. And 12:05 Speaker 0: as he said that I go, Where's my trampoline? My trampoline's gone. 12:10 Speaker 0: It wasn't that trampoline because he didn't live anywhere close to me, but like the wind took my trampoline and took it somewhere. 12:16 Speaker 0: Did you ever get it back or was it broken? We looked in the canyons and figured like- You literally couldn't drive jumping on it or something. 12:22 Speaker 0: Know, but they weren't. Somebody has it. So anyways, my wife bought a new 1 and Jared comes out to 12:30 Speaker 0: put it together. Cause I was working, just put 12:33 Speaker 0: it together all wonky. 12:35 Speaker 2: Jared. And 12:38 Speaker 0: I'm gonna pay you hourly to Yeah. Fix 12:42 Speaker 2: Oh man. But 12:45 Speaker 0: listen, we're blessed. Life is in full swing. 3 12:48 Speaker 0: You're getting married. 12:49 Speaker 0: Kids, I just had a granddaughter. My 2nd granddaughter life is good. 12:53 Speaker 0: We had good lives, man. Like, she's 12:56 Speaker 0: like safe and healthy and the kid is good. Yeah. So she's healthy. My daughter is a, it's crazy when your daughter has a daughter daughters, 13:04 Speaker 0: but you know, life gave me another swing and I'm glad I have boys because daughters are hard. Yeah. 13:10 Speaker 2: Teens are like, 13:11 Speaker 2: woah, 13:12 Speaker 0: But like kids, boys are hard now. 3 5 and 2? Yeah. 13:17 Speaker 0: Dude. Yes. It is just freaking kidding. They just want to run around and break My God. My 13:24 Speaker 0: God. 15 minutes at this office. And it's like the office is in shambles. 13:28 Speaker 0: But then boys were here. I don't see. Dude, you know, this is gonna be cool thing is like that, like, I'm going to try to work on like, you know, kind of living like your mom where it's like, you know, I always had the most patience. I'm working on that stuff, but like let them be boys, boys. Need to break shit, dude. They need to climb shit. They're going to probably break their arms and they're going to rob, but they need to test the limits of stuff. They're full of testosterone 13:48 Speaker 0: and we support that in our family. You know what I mean? Not just sit in a chair for 8 hours and like study some shit. You're going to like, forget 13:57 Speaker 2: like, like your mom, like she touched it, feel it. That's what my wife is good at. Like she will she's like right now with she's like the science, she's some science thing. That's cool. She would take me there all the time. Have this Pacific science center in Seattle. That's how you learn. Absolutely. It was great. That's great. And right, with River the other day, we had a dresser that has been out not used for a long time. I'm like, dude, I'm done with this dresser. I said, River, come here. You're gonna help me take the trash out. He's like, I'm like, come on. Grab the axe. You're gonna we get to break some shit. And he's like, okay. Alright. Yeah. And so I put the dresser in the side and gave him an axe. Luckily, he put his baseball helmet on because I could just see this thing go bounce 14:35 Speaker 2: right back at him. And then he got to just just beat the hell out of this dresser, just destroy it, break it down so then I could just nicely put it in the garbage can. His mom came out about 9 times and was like, don't do that. Why? I'm like Yeah. Stuff. He's a boy. Like, he needs this 100%. And literally it was like, that's the most fun I've had in so long. Know this is what they needed. The boys just need, he needs to, they need like, they just need to be able to, yeah, loud noises 15:02 Speaker 0: break should use their strengths. I try to catch myself 3 when I'm like getting irritated. I'm like they're boys, dude. Yeah. Break some shit guys fighting on out. They're fighting all the time. They're gonna be, it's gonna be Mason's gonna beat him. Beat Jack's up somewhat soon. He's my 15:18 Speaker 0: son. Jack's was like so daring. Like he was so ballsy when he was literally kind of turned into a little crybaby. I'm trying to, I got him toughen this kid up. 15:26 Speaker 0: Mason's gonna whoop his ass. I'm like, Jack's gonna eat your food. Mason's gonna kick your butt dude. Like, so Mason will walk by and like bash him in the head with a toy and then Josh starts crying. I'm like, hit him back, dude. Yeah. You're his older brother. I was like, what? I'm like, dude, they're gonna be brawling, dude, whatever. Yeah. 15:42 Speaker 0: So they'll learn to settle in. So anyways. My sister did. I mean, judge right now, you listeners, hear you. Yeah. 15:51 Speaker 2: Sister's got an older boy. Who's not, 15:54 Speaker 2: I don't know. He's like borderline the gas burgers. Right. And then, and then the younger daughter, and I remember we were in Hawaii 1 time and the boy came up to mom and said, hey. It's like she took my she took my airplane crying. She's like, you're her older brother. Take it back. Yeah. Don't 16:12 Speaker 2: come crying to me about this. 16:14 Speaker 0: Anyway. No crying a lot. I always say, this is the no crying section. You can cry all you want in your room. This is no crying section. Wow. 16:22 Speaker 0: Now that 1 you might get judged on, but whatever. It is what it is. Not perfect. No asshole. You gotta people know you know when you go out there, but can't cry. I'm like, listen, dude, I'm a father at 1st, so they can't Here's the thing with the crying, it's like, dude, especially the pain crying. 16:35 Speaker 2: Ugh. You fucking hurt yourself crying. Other than that, dude, stop crying. I think that, like, real I mean, kids cry about everything, and just attention. So that's very, so that's good. But now as an adult, like pain is not in, does not trigger a crying response 16:49 Speaker 2: for an adult. Yeah. I don't know. I don't know. But not for me. Right? The only thing that triggers a crying response is like my dog dying. Yeah. Like real emotional thing. So I don't know if the kids 17:00 Speaker 2: I get scared, but the scaredness, this pain, they think it should hurt. So it's crazy with always with kids. Right? They do something. If you look at them and go, oh my gosh, are you okay? Yeah. Bam. Cry. And for me, If you go, get up. You're fine. Yeah. I do not like it all time. Well, he didn't wanna go. You gotta hear us being a little butthole when he came, like, throwing a little fit and, like, he didn't wanna do jiu jitsu. And I'm like so I talked to him. 17:23 Speaker 0: He ends up getting a stripe. Right? So I tell him after I said, listen, if you didn't go, you wouldn't have got that stripe. 17:28 Speaker 0: And 2, there's another, there's another father there that runs a kickboxing class and he's cool. He's really hard on the son, you know, and like, I like that type of stuff. It makes, it makes him a man. So 17:37 Speaker 0: he, his son was kind of messing around, 17:40 Speaker 0: made him stay after class and they ran around the 17:44 Speaker 0: thing, like think 6 times. So I was going to do that with Jackson yesterday. Was gonna literally put my shoes on and be like, listen, you're either going to GJ 2, you're not going to play complain or I'm you and I are running around this and you're going to run around this parking lot 6 times. So we ended up going to, I was literally going do it because I thought that guy could get that. I'm like, well, that's, that's good. So, 18:03 Speaker 0: especially when you do it with him, I will do it with him because I'm gonna teach him that I'm gonna do it too. Well, I say this a lot. I mean, I'm not gonna ever ask anybody to do something that I wouldn't do. For sure. And I'm gonna teach him that you're gonna either do it or you're gonna do something else harder. 18:17 Speaker 0: Toughness will suck her up. That 18:19 Speaker 2: was good. Good view. Shit, when I was in college football, if you were injured, like you had to do the most humiliating 18:25 Speaker 2: things like Oh, really? You literally so if you were injured and you weren't practicing, you had to gear up full pads. You may not take your helmet off, 18:32 Speaker 2: stand on that sideline. You also had to but 1st you had to gear up helmet on and go into the training room. And if you had an injured right leg, you're on the bike with your 1 leg inside wearing all of your gear. 18:45 Speaker 2: It sure makes you be like, okay, dude, I'm good. Like, I'm gonna go run. Can I play? Going back on the field. I remember those days. 18:53 Speaker 0: I never missed the game. 18:56 Speaker 2: Yeah. Played hurt. Yep. Absolutely. Was in college. You start to realize like, man. Oh, I freaking loved it. Yes. We all done it right. And I broke my thumb. My thumb was in my wrist. Hear I was like in the huddle, like, I think something's wrong. 20:01 Speaker 0: So 20:02 Speaker 0: dig into it, man. Tell us a little bit about NAD. 20:04 Speaker 2: We have a graphic here. And 1st 20:08 Speaker 2: of all, I guess the big thing is, is so NAD is a co enzyme, right? It is not actually a peptide, but 20:16 Speaker 2: semantics, 20:17 Speaker 2: whatever. It 20:19 Speaker 2: is, I'm not gonna even say the name. Yeah, that's rough. Nicotinamide 20:24 Speaker 2: adenosine, 20:25 Speaker 2: I don't know, something more than that. But it's everywhere. It's everywhere in your body. Like, everything 20:31 Speaker 2: depends 20:32 Speaker 2: on NAD. 20:34 Speaker 2: Right? 20:36 Speaker 2: It will so here's some of the benefits. Like, NAD is is where it is it is it's working in your cells on a biological and genetic level also. Okay? So Push your limits, train with precision, see the results. 20:48 Speaker 0: At Equinox, that's high performance loving. 20:51 Speaker 0: Iconic spaces that inspire. 20:53 Speaker 0: Personal training backed by real data, unlimited group fitness classes from yoga and pilates to strength and conditioning. Elevate your post performance ritual with saunas, steam rooms, cold plunges, and more. Everything you need to lock in and unlock your potential at Equinox. Start today at equinox.com. 21:16 Speaker 1: Ultra running shoes are all about space. 21:19 Speaker 1: The space to go further, 21:21 Speaker 1: to feel better, to do something you never thought possible. And this space starts with UltraFit. 21:27 Speaker 1: Unlike traditional running shoes, UltraFit gives toes more room to move naturally, 21:32 Speaker 1: so every step is strong, balanced, and comfortable. 21:35 Speaker 1: Whatever you're lacing up for, stay out there with Ultra. 21:39 Speaker 1: Shop now at ultrarunning.com. 21:41 Speaker 1: That's altrarunning.com. 21:45 Speaker 2: It's what is creating a lot of your ATP. Synthesis, 21:50 Speaker 2: which is, that's what happens in your mitochondria. This is why MOTS-3C also helps with ATP 21:54 Speaker 2: because it is, it's, it's helping kind of give some fuel to your mitochondria. So 22:00 Speaker 2: NAD is going help with your natural energy production. Okay? And that's not caffeine energy. That's not like stimulant 22:06 Speaker 2: energy. That's cellular 22:09 Speaker 2: energies. 22:10 Speaker 2: Adenosine triphosphate, I will say that's the name of ATP. 22:14 Speaker 2: So energy production, right? DNA 22:17 Speaker 2: repair is actually gonna Huge. Repair some of these strands and 22:22 Speaker 2: cellular repair and just repair as our cells slowly die off, right? NAD is gonna repair them 22:27 Speaker 2: so they don't die as fast. Guess what? We are old because 22:32 Speaker 2: all of our cells are dying and not regenerating fast. They always kind of regenerate, right? But they're not growing back and they're not regenerating building to what they once were. So it's kind like 22:45 Speaker 0: if you're taking it like SubQ, you're injecting 22:49 Speaker 0: autophagy, 22:50 Speaker 0: a dye 22:51 Speaker 0: off or repair. So 22:53 Speaker 2: kind of, because it's going to repair those. That's I say, that's why I guess the tag as antiaging because it repairs the DNA. Yep. And like FOXO-four folks, we don't ever really talk about that, but that that's that peptide's job is to just clear away dead cells. So it's kind of a nice mix on things where, like cells will die. I don't care if you're taking NAD, 23:11 Speaker 2: your cells are always dying and replicating, 23:13 Speaker 2: but this helps repair like DNA 23:16 Speaker 2: repair. 23:17 Speaker 2: Okay. 23:18 Speaker 2: It will, and absolutely, it's gonna help your brain, your brain health, right? It's neuroprotective. 23:22 Speaker 2: You people will notice 23:24 Speaker 2: more mental clarity, 23:27 Speaker 2: you know, 23:28 Speaker 2: sharper, 23:30 Speaker 2: thoughts, which my brain isn't working right now. We just talked about this whole thing before and we both said, shit, I gotta, I gotta take a little bit more and it's time for me to get back on. It's been a while, which I will like tonight starting now. 23:44 Speaker 2: Heart metabolism, it's going to improve insulin sensitivity, right? Better control your lipids, which is your fats 23:50 Speaker 2: and your cardiovascular function. 23:53 Speaker 2: Everybody wants their heart to work better, regulates inflammatory pathways and supports immune 23:58 Speaker 2: cell responses, everything 24:01 Speaker 2: in longevity genes, 24:03 Speaker 2: regulating 24:04 Speaker 2: healthy aging. So 24:07 Speaker 2: there are, what's this, what's this stat here? There's 500, 24:10 Speaker 2: there's 500 enzymatic reactions depend on NAD plus it's everywhere in your body. I mean, obviously everything is made of cells, but 24:18 Speaker 2: our body depends on NAD and it functions 24:21 Speaker 2: very well with a lot with, with good levels of NAD. 24:25 Speaker 0: And 24:26 Speaker 2: it's important everywhere. 24:29 Speaker 2: The, this is an interesting graph. So I, this is something actually new to me. NAD 24:34 Speaker 2: declines dramatically with age. Okay. 24:37 Speaker 2: I wish I can. I'll tell you what this is later, but so at birth a 100% age, 82% 24:42 Speaker 2: age, 55% 24:44 Speaker 2: age, 60, 34%. 24:48 Speaker 2: That's a huge drop off. And 24:51 Speaker 2: therefore we're meant to have this 24:53 Speaker 0: probably 80 to 100 percent. 3 Okay. NAD plus you go down, let's talk about that for a 2nd. So as you go down where you're losing NAD, you got fatigue. 25:02 Speaker 0: You're to have obviously the typical brain fog. You're going to just kind of just be obviously tired. 25:07 Speaker 0: So if 25:09 Speaker 0: in the 40s, 50s, and 60s, and you don't take this, it's time to- 25:13 Speaker 2: get to the 80. 25:15 Speaker 2: As you write late 30s, it's time to take NAD. I 25:19 Speaker 0: always tell people, 25:21 Speaker 0: you know, if we just always slow down and use our brains and think logical, Like to the, to the, to the compounds that most 25:28 Speaker 0: movie stars take 25:30 Speaker 0: are HGH 25:32 Speaker 0: entity. Why? Because they freaking work. Why would they take it? Because somebody a lot 1 more intelligent than them told them to take it because it's for anti-3s. And they 25:43 Speaker 2: have- The top of the knot line. More resources depend on them being in shape and right now. 25:48 Speaker 0: So if they do it, they probably should do it. That's why I love HGH and I'm NAD. So there's all the kind of basic, 25:56 Speaker 2: basic functions. 25:58 Speaker 2: Then talking about, there's a couple of ways to take into it. People have heard about these. There's with BPC NAD plus oral pills. 26:07 Speaker 2: You can go to a med spa and get a, like an NAD drip. So they tap into your actual vein 26:13 Speaker 2: and with a bag and drip it in there. 26:16 Speaker 2: Or you can buy the peptide vial, right, and reconstitute 26:21 Speaker 2: and draw up and SubQ injection yourself. 26:24 Speaker 2: Frankly, 26:26 Speaker 2: the pills not 26:28 Speaker 2: worthwhile folks. Would just not waste your time with the true NAD plus finished product pills. The 26:35 Speaker 2: so the 26:36 Speaker 2: SubQ version is, well, it's a 100% bioavailable in your body, right? You 26:41 Speaker 2: it actually helps you with you absorb it real fast, but it sustains release. It stays in you a little bit a lot longer. And the name of the game, I guess, is still just kind of level. We want, we want level amounts 26:52 Speaker 2: versus an IV drip. We're just blasting a whole bunch in you at 1 time, and 26:57 Speaker 2: then you're stopping, 26:58 Speaker 2: okay, for a while. So my suggestion is subQ 27:02 Speaker 2: route 27:03 Speaker 2: daily or 3 days a week, for sure. 27:06 Speaker 2: It's going to be a lot better. Also the 27:09 Speaker 2: pills tend to mess up some people's GI tracts and have 27:12 Speaker 2: issues there. 27:14 Speaker 2: Again, cognitive clarity, energy, stamina, sleep recovery, cellular repair, the whole thing about cellular repair, right? The, 27:23 Speaker 2: and back to that other graph, right? This is why 27:27 Speaker 2: we get old guys. We get old. We look old because our because our DNA, our genes, and our cells 27:34 Speaker 2: just don't grow as strong. They don't repair as well. So, I mean, this just says it all. I'm 27:40 Speaker 2: gonna be doing a lot of a lot more NAD folks, and 27:44 Speaker 2: I notice it. You do? I know a lot of people I don't quite 27:48 Speaker 2: I didn't right off the bat notice the mental 27:51 Speaker 2: energy, 27:52 Speaker 2: but I had noticed the look like after 2 months of taking it, my skin looks like tighter. Yeah. 27:58 Speaker 2: And I have more physical energy and just feel a bit, feel better. Yeah. 28:03 Speaker 0: I think because 28:04 Speaker 0: we, a lot of people start with the 2, we call them gateway drugs for lack of a better way to say it. BPC-five 28:11 Speaker 0: hundred, if you have an injury and then you try those, you're like, wow, that does amazing or GLP-1s, 28:16 Speaker 0: which are instant gratification. 28:19 Speaker 0: So you start there, but most peptides, 28:22 Speaker 0: most of the rest are not going to be the instant gratification where you feel it really necessarily. 28:27 Speaker 0: Need to take them for months 28:29 Speaker 0: for most. And it's not like you feel it. Oh wow, I feel the NAD. I mean, you can, but you're just going to notice that you look better. HGH is noticing you can burn fat better all of a sudden. That's 28:42 Speaker 0: how most peptides 28:44 Speaker 0: are. We're 28:45 Speaker 0: humans and we are programmed to want instant gratification. 28:49 Speaker 0: And that's just not how most of us oftentimes 28:52 Speaker 2: you notice these a lot when you stop taking them. You don't really expect that was happened to me earlier. Yeah, I 28:59 Speaker 2: took HGH for a while. I'm like, I don't even know what it's really doing. Is it doing? Then I stop and a month later I go down. Now I know what it was doing. Holy shit. Like I've, it's so much, my body was so much more forgiving on it, you know? But now if I'm off whatever I eat, okay, I can see that affecting me negatively. Whereas before it would just burn everything off. So it was kind of somewhat similar to NAD. 29:24 Speaker 2: So look at the bottom here, 29:26 Speaker 2: suggested dosages for kind of different uses, right? General wellness. 29:31 Speaker 2: And I will put a caveat guys. 29:34 Speaker 2: They do the doctors. So a typical like IV drip and doctors are giving 2 50 micrograms, but most commonly 500 29:41 Speaker 2: mg, excuse me, milligram, 500 mg, even 1000 mg 29:45 Speaker 2: in a bag and giving it to you in 1 session. 29:49 Speaker 2: That's a lot, right? So thousand milligrams. Now it needs to be over several hours because 29:54 Speaker 2: NAD 29:55 Speaker 2: burns. If you squeeze the IV bag and get it into you faster, it will burn like hell. So you want to slow drip it, but 30:03 Speaker 2: you can you can take a lot if it's tolerated for the individual. So general wellness down here, like 15, 25 mgs, 30:10 Speaker 2: 3 days a week. Work your way up. All of these, you do not start at any of these doses that you see folks 30:16 Speaker 2: anti aging longevity, 30:17 Speaker 2: 50 mg 30:19 Speaker 2: to 200 mg. There are 30:23 Speaker 2: research and clinicians 30:25 Speaker 2: like 30:26 Speaker 2: telling people, Hey, up to 200 Migs, 30:29 Speaker 2: right? 3 days a week. That's a lot. That's a lot. 30:31 Speaker 2: Cognitive 30:32 Speaker 2: performance, 30:33 Speaker 2: 25 to 75 mg daily to 3 days a week. That sounds right. 30:38 Speaker 2: Recovering 30:39 Speaker 2: fatigue, 30:40 Speaker 2: 100 mg to 200 mg as needed. And 30:44 Speaker 2: then this actually says clinical and must be administered by a like medical professional, 500 mg 30:50 Speaker 2: daily, 30:52 Speaker 2: but that we're talking about is the IV bag. Okay. 30:55 Speaker 2: So 500 to 1000, I've known people who've done the thousand 30:59 Speaker 2: with a doctor. 31:01 Speaker 2: Then we have a little bit more details on this. So how do you, so you will see. So as far as the peptide is concerned, this is kind of what we're here talking about is you're buying your bottle with 31:12 Speaker 2: lyophilized powder. Okay? You'll see 2 50 mg, you'll see 500 mg, 1000 mg. So I really just have 500 mg and thousand here. So 500 mg, let's make life easy. These should always come in a bigger bottle because 31:27 Speaker 2: you need to add a decent amount of water in. If you have 500 mg, 31:31 Speaker 2: add 5 mils of water. If you do that, then it makes it very easy. 1 unit is even a 1 mg. Yeah. Right? So 10 units is 10 mg. 31:41 Speaker 2: The 31:43 Speaker 2: thousand milligram bottle, 31:45 Speaker 2: you're going to add 10 mils of water and therefore the conversion or that same ratio is the exact same. Also people, you will see your 31:54 Speaker 2: NAD usually in an 31:57 Speaker 2: amber bottle. People ask me all the time, why is that? Well, it's to block light. So 32:03 Speaker 2: NAD is particularly sensitive to light. It is not particularly sensitive to heat. So storing at room temp is is just fine. It can't be too hot, but like it doesn't need to be refrigerated. And in fact, it's probably a good idea to even 32:18 Speaker 2: draw it up, then kind of leave your, leave the syringe, let it warm up to room temp. And as you inject, it will burn a little bit less 32:25 Speaker 2: suggested tip. So on the 500 32:28 Speaker 2: on both of these, 32:30 Speaker 2: I personally generally think like 25 to 50 mg, 32:34 Speaker 2: 3 times a week is about where a person wants to be. Okay. Now 32:39 Speaker 2: start though at probably 10 mg, 32:42 Speaker 2: I would start my 1st dose would be 10 mg and I would bump up by either 5 or 10 until I get to 25 or get to 50 where you want to stop at. If you do too much, and I personally have done too much accidentally 32:56 Speaker 2: early on, I think I did like 80 mg, like this 3rd, 2nd and 3rd shot, and 33:02 Speaker 2: I did that in my stomach. 33:04 Speaker 2: As soon as I did it, I got some tingling in my hands and feet, and it rushed up and became way more intense, 33:11 Speaker 2: and my nasal cavity just went, 33:15 Speaker 2: bam, just 33:16 Speaker 2: closed and flamed like this, like, boom. I was sitting down luckily and luckily I've been through some weird shit before, but I literally had my phone in my hand. I remember in this stuff, the wave of tingling just 33:28 Speaker 2: easy 33:29 Speaker 2: and tense and I was paralyzed. I remember trying to like flex my hand and my stomach and like nothing would work. Woah. Brain was done and I just, so just 33:38 Speaker 0: breathe. This is how it is. This is how it ends. No. This 33:42 Speaker 2: ain't going to kill me, but I just breathe through it. I know that I've done some dumb things in my life, but if I was a normal person, 33:49 Speaker 2: would have scared the hell out of me for sure. And 33:53 Speaker 2: I thought, okay, hey, if I get, if I'm passing out anymore, I do have a friend who's upstairs. Better, let's see if I can get a yell out, but I'm not gonna do that quite yet. We'll ride it out. That lasted about 15, 20 seconds or so. And then it slowly 34:06 Speaker 2: went away. 34:08 Speaker 2: My nose took a couple hours to like unclog. 34:11 Speaker 2: Oh, wow. And so don't do too much right off the bat. 34:15 Speaker 2: So when we say if tolerated, 34:18 Speaker 2: that means you're gonna you need to slowly increase. Now you're you build a bit of a tolerance, but I know people who say, dude, I love doing NAD where my, where I want to do my dose is where I do it and I get tingly, 34:30 Speaker 2: but they're not talking about overwhelming tingly. Okay. 34:33 Speaker 2: So that's okay. It's not a bad sign. You just need to know where to draw the line. Capture. 34:40 Speaker 0: Now 34:41 Speaker 2: I do know a 100%. I know people that are doing 100 mg every day. 34:46 Speaker 2: They're 34:48 Speaker 0: still alive. I was doing 50. I was doing 50 pretty probably 6, or 7 days a week. I was doing it at 02:00. Because we've 34:56 Speaker 0: talked about it before, but when I hadn't been taking it, but as Will said, I'd probably start taking it again because it's been a while and 35:03 Speaker 0: it's so awesome, it does so much. 35:07 Speaker 0: But our good friend Paul was coming on next week again is, he had suggested to take it at 2 instead of coffee because I'm a 02:00 35:14 Speaker 0: crash coffee guy. I get up so early and 35:17 Speaker 0: it worked great. And that's when I would take it. And I would take, I would kind of settle that 50 megs daily and it worked great for me. And, know, often starting this, I have heard, and I know that this can happen when you're 1st starting, 35:30 Speaker 2: it can actually do a little reverse job on you and you can feel a little bit tired. The 1st couple of doses, similar to growth hormone. When you start growth, you do feel man, a little life worn out for the 1st couple of weeks. If you just move through that, it will go away. 35:43 Speaker 2: Your body is doing and repairing a lot of things that it's not used to. So it's burning off, well, it's burning some extra calories, you know, rebuilding your cells in the part of HGH, like rebuilding muscles. 35:55 Speaker 2: So that takes maybe a little toll at the beginning, but just ride it out and it should be fine. 36:01 Speaker 2: Again, IV IV drips here, 36:04 Speaker 2: 500 mg to 1000 mg in 1 session faster this session, the more it burns. 36:09 Speaker 2: So how about this? Here's NAD for me personally 36:13 Speaker 2: burns like a son of a bitch and like almost to the point where I don't want to do it. 36:18 Speaker 2: So I use no sting water and it works perfect. 36:21 Speaker 2: And that makes it a 100% bearable, but warming it up, injecting slower, 36:26 Speaker 2: Injecting in, just let it slowly kind of go in is gonna burn a whole lot less. It's also doing that inevitably is going to reduce the risk of any type of reaction because you have your 36:37 Speaker 2: histamines, 36:38 Speaker 2: if you put a whole bunch in, you get a whole bunch more of a histamine response. Right? They come rushing to the party. If you do just a little bit at a time, you're not going to get as many histamines all at once. So a tip for other things as well. 36:50 Speaker 0: Yeah. Testosterone is like that for a lot of people, a lot of people will just, if you just go slow, 36:56 Speaker 0: you get a lesser chance that you're going to get PIP because you're going super slow instead of just blasting all that oil into that section. It's the same thing with testosterone. You do too much too fast, absolutely can start to make you better. I know people even got sick. 37:10 Speaker 2: Which is pretty much hormone 37:12 Speaker 2: hitting you all at once. It's a shock to your body. Sure. Everybody's so radically different. So Will's talked about having a 37:19 Speaker 2: stinging forever. 37:21 Speaker 2: I 37:22 Speaker 2: remember when you had done that, I wasn't there, but I remember when you did it because you were talking about it. 37:28 Speaker 0: I've just never had that experience and it has never stung for me, you know? So, 37:33 Speaker 2: it's everybody's just so radically different, You can do this stuff, intravascular tube. Want to just pop it in your thigh? Yeah. Like similar to Glutathione. That's what I do. You can. Yeah. 37:43 Speaker 2: So there we go with NAD. 37:46 Speaker 0: It's great. If you've not done it and you're listening to this, you'd need to do it. Like 1 of the things that most people should start with is Epitalon, you know, and get that done. Then, but NAD is a must. 37:55 Speaker 0: It's a must. 37:57 Speaker 0: Generally speaking, just 37:59 Speaker 0: like if you put too much water, it's not exact on anything. You don't ruin the compound. 38:06 Speaker 0: Generally speaking, I think we've always kind of go in cycles of 1000 mg. We've always kind of gone off that kind of, you know, we've changed in the beginning, I think, much we were telling Okay, 38:16 Speaker 0: fair enough. Run it through a true cycle of 1000 megs, maybe take a month off and then run another however long it takes you to do 1000 megs. 38:25 Speaker 0: That's of, you kind of go by that. It's kind of worked well. That's worked well. Yeah. So like however many, if you need to, yeah, 38:32 Speaker 2: if you buy just a bottle, 1000 mg bottle, 38:35 Speaker 2: there's no time limit on it. If it takes you 6 months, it takes you 6 months. Right? But if you can finish that in a month while you're doing a lot, but that's okay. We did discuss 38:45 Speaker 2: 1 good idea is, Hey, in between 1000 mg, right? Give yourself a little break. So 38:51 Speaker 2: 2 to 4 weeks. 38:53 Speaker 2: And in 38:54 Speaker 2: between there's take the oral NMN, 38:57 Speaker 2: which is not NAD plus So NMN is the precursor to NAD plus So you take that, body starts being able to gives building materials essentially to make more NAD plus. So in the midst of that, in the midst of that 1, pull up the next slide. In 39:13 Speaker 2: the midst of that, 39:15 Speaker 2: in that break time period, NMN 39:18 Speaker 2: almost like it was a post cycle riot, just like replenishing your body with the building materials for NAD and then repeat. 39:24 Speaker 0: I would say- Yeah. Over the little like 39:27 Speaker 0: way to do this would be maybe run NAD 39:30 Speaker 0: and then take a break from NAD and then run-in some MOTS-1MQ and SS-thirty 1 and then switch them. Absolutely. Because if you take MOTS-1C and SS-31for too long too, you will get run down. It will overdrive the mitochondria. 39:41 Speaker 0: You speak with experience. It took me a while to like figure that out, but you know, live and learn. That's a good point. Good point. So there it is with NAD. Yeah. 39:51 Speaker 0: If you haven't done it, do it. 39:53 Speaker 2: There's a reason that like every single med spa is offering this and movie stars and everybody, and it's got a big name. It works. There's a reason it works. 40:02 Speaker 2: Next thing we get into Tesofensine. 40:03 Speaker 2: So now that we have this up here, Tesofensine 40:07 Speaker 2: is definitely not a peptide. 40:09 Speaker 2: It's more closer to like a pharmaceutical 40:12 Speaker 2: drug. 40:13 Speaker 2: It's really interesting. Any of those, any of you people who have done any, well, 40:17 Speaker 2: any like 40:19 Speaker 2: SSRIs, 40:20 Speaker 2: so Zoloft, 40:21 Speaker 2: Wellbutrin, 40:23 Speaker 2: this is, well, it's a mix of these. So Tesofensine 40:27 Speaker 2: is 40:29 Speaker 2: a triple, 40:31 Speaker 0: whatever, 40:33 Speaker 2: reuptake inhibitor. 40:34 Speaker 2: So it has a, it's a selective 40:36 Speaker 2: and SSRI, which is a selective serotonin reuptake inhibitor, which is what Zoloft is. And serotonin 40:43 Speaker 2: is the neurotransmitter that makes you happy 40:46 Speaker 2: but calm. 40:48 Speaker 2: People, docs will give it to people who have anxiety and depression. 40:52 Speaker 2: Then you have the dopamine reuptake 40:54 Speaker 2: inhibitor, which is like Wellbutrin. 40:57 Speaker 2: That makes you happy but energized. 40:59 Speaker 2: A lot of people will get that for not stopping smoking, 41:04 Speaker 2: And that works also. And then finally, this is a norepinephrine, 41:09 Speaker 2: AKA noradrenaline 41:10 Speaker 2: reuptake inhibitor, which makes you happy 41:14 Speaker 2: and really energized. There's not many people I know that are taking a pure 41:18 Speaker 2: norepinephrine 41:19 Speaker 2: reuptake inhibitor. I think they do exist, but I've never 41:23 Speaker 2: I've been on both of these. 41:27 Speaker 2: Again, we talked about this last time. Like, I went to I've been to treatment and was depressed when I got out. Duh. 41:32 Speaker 2: As I was putting, like, massively bad things in front of my brain into my body constantly, and then you stop them and you feel depressed. So I was put on serotonin, 41:41 Speaker 2: Zoloft for a while. It made me too sleepy. Like, I was just too, like Push your limits, train with precision, 41:47 Speaker 0: see the results. At Equinox, 41:50 Speaker 0: that's high performance loving. 41:52 Speaker 0: Iconic spaces that inspire. 41:54 Speaker 0: Personal training backed by real data, unlimited group fitness classes from yoga and pilates to strength and conditioning. 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And frankly, after a while, after I was sober for a while and like had a good connection with God and people and and started living life, 43:04 Speaker 2: I was able to cut both of them off. And 43:06 Speaker 2: I will say this, the the Zoloft 43:09 Speaker 2: is the 1, if you just stop cold turkey, there's a little bit of withdrawal symptoms. Yeah. Yeah. I think there there's said to be withdrawal symptoms than the others, but I didn't really feel it that much. But anyway, I started taking Tesofensine. 43:19 Speaker 2: So here is how it is all 3 of those combined, but it's not just full strength, it's 43:25 Speaker 2: actually a better mix and I can't really get into the details of it, but it's 43:29 Speaker 2: about 43:31 Speaker 2: a natural occurring version and safer on you. 43:34 Speaker 2: How it is So it was 43:36 Speaker 2: started as a treatment for Alzheimer's and Parkinson's. 43:40 Speaker 2: And then during their early neurological tests, started realizing why is every single patient losing a bunch of weight? 43:46 Speaker 2: Wait a minute, let's maybe switch the research. And so now it's literally like 1 of the most potent 43:52 Speaker 2: weight loss drugs. Well, 43:54 Speaker 2: GLP is knock it out of the park, but 43:57 Speaker 2: this is what it does. It is here to help person lose weight. Why? But it just affects your brain. So it is essentially 44:05 Speaker 2: taking away the craving for 44:08 Speaker 2: any trying to get a dopamine spike. Your brain is just happy how it is. It doesn't need its sugar. It doesn't need food 44:15 Speaker 2: for happiness. Yeah. And believe it or not, I know most of you people are like, don't eat food for happiness, but you do and it does provide you happiness, especially 44:23 Speaker 2: the sweets at night. This stuff is crazy. You take it and you, 44:27 Speaker 2: JD will kind of give us a personal experience, but 44:30 Speaker 2: it's the sweets. I'll be eating the ice cream and go, this just doesn't do it for me at all. I don't know why I'm doing this. It's it does not provide the same, you know, happiness that it used to, and so what's the point? So then I don't do it. Doesn't even taste good. I 44:43 Speaker 2: don't get I personally don't know. I don't get fat from steak and potatoes. 44:47 Speaker 2: It's not going to prevent me. It's not going to reduce my hunger. Yeah. Right? I still, by a large, I need food, 44:53 Speaker 0: but it is going to reduce any of that bad food that just gives makes my brain artificially happy. Yeah. And that's the point. Yeah. So what have you I know you just started taking it. I know you've had some- Yeah, it's definitely been an interesting 1 for me because I think I misjudged it and sometimes I have to take our own advice, which, you know, I don't always do that, but I'm gonna give it sometimes and not always following it. But when I had gone to Cancun, I took it for 3 days and because we were studying it at that time and talking about it, I was super intrigued. 45:20 Speaker 0: And I went out for a wedding that I was actually going to, what do you call it? Pastor? What do you lead? Yeah. 45:28 Speaker 0: Was my cousin's wedding. It was a kind of a big ordeal 45:30 Speaker 0: and I was, 45:32 Speaker 0: I felt just so off. I felt tired off. 45:36 Speaker 0: Is, you know, I'm trying to break down, what did I change in my protocol? 45:40 Speaker 0: And that was it. So I pulled it and didn't fill that anymore. So I figured I left thinking it was a Tesofensine. I've never been in on an SSRI. 45:48 Speaker 0: Thank God I never 45:51 Speaker 0: went to a rehab that did that because man, that's 1 of the reasons I hate Western medicine. They just here take a bunch of shit, 45:56 Speaker 0: get y'all these drugs and here's some more drugs. Like my wife was on like 8 drugs out of a rehab dude. 46:02 Speaker 0: They give you the pills. 46:04 Speaker 0: Know what mean? 46:06 Speaker 0: That's a different subject. But anyway, so I, for the longest time, not talk about it forever. I just wasn't a fan of it. Now we 46:13 Speaker 0: did, we've 46:14 Speaker 0: had other people on the show, we've had it, we've talked about it numerous times. Everybody's really loved it. So I've been super intrigued by it. I'm like, maybe I didn't give it a fair shake. 46:22 Speaker 0: And so the last month and 0.5 or so, give or take, I wasn't taking hardly any, so I did start taking it and 46:29 Speaker 0: gosh, it gave me a lot of energy. Right away, if I noticed it, I was like, wow, that So now I wake up and then I go downstairs and push coffee and I take Tesofensine and I feel like it wakes me up. It's 46:41 Speaker 0: great. I feel like focused. I 46:44 Speaker 0: do not feel any 46:46 Speaker 0: of the 46:48 Speaker 0: blocking of the sugar cravings. Like I'm dealing with the sugar cravings at night right now. I'm dealing with some gut stuff, so I think it has to do with some of that stuff 46:56 Speaker 0: because I like the sweets at night. Now I'm you. Yeah. Never really had that problem now. So I wish the Tesofensine would kind of block some of that, but 47:06 Speaker 0: it does what I need, what I like it to do, which is that focus. But how long have you been on it now? Probably 47:11 Speaker 0: 3 weeks. Oh, okay. I'd 47:13 Speaker 2: say because most of these antidepressants 47:15 Speaker 2: also, 47:17 Speaker 2: need to put some weeks in before they actually know it will work. It's definitely not like a narcotic where you just pop it and think. Now maybe the energy part of it, it is pretty fast working. Yeah. 47:27 Speaker 2: I'd give it a little bit longer. I mean, I would generally say 3 weeks is probably enough time for you to start to feel that. 47:33 Speaker 0: It's not a 47:35 Speaker 0: jittery energy. It's not like 47:38 Speaker 0: a tweaky type, you know? It's very focused. 47:42 Speaker 0: Will and I were talking off camera about it's a little bit Modafinally. 47:46 Speaker 0: I love Modafinil. I usually take a Modafinil before most podcasts because it's just super focused. If anybody's taking it, you'll know what I'm talking about. 47:54 Speaker 0: So it has a little bit of that flare to me. You focus a little bit more, you definitely have more energy. So the food part for me isn't that big of a deal. I'm pretty disciplined with that stuff. I can handle that stuff. 48:04 Speaker 0: But a lot of people say that, that it's not necessarily 48:08 Speaker 0: rivaling a GLP-three, 48:10 Speaker 2: but it's definitely right behind it. And a lot of research is showing literally, I mean, they're doing, they're doing active research studies and it is proving that it's helping weight loss. 48:22 Speaker 2: But the energy for sure, I absolutely, 48:25 Speaker 2: and it's not even artificial energy. It is just Yeah. It's the dopamine increase. It's like when your brain If you're happy 48:33 Speaker 2: and motivated about something, you have more energy. I promise you. Like you are like, shit, I'm Let's get out of bed. Let's do this thing. Right? 48:40 Speaker 2: Imagine every day of your life, even those who are depressed when it was Christmas morning or Sunday, you know, whatever today you were doing was gonna be awesome. Yeah. You were up out of bed. Yeah. And excited about it. Right? And you had energy. This is what it does. It doesn't increase your heart rate, right? It doesn't nothing like that, but it does, it increases that dopamine. So you just feel a bit more motivated and you just, damn, I want to 49:03 Speaker 2: work and not take a nap and I don't want to miss any of the day because I feel happy and ready to go. I noticed that for sure. Sure. 49:10 Speaker 0: So 49:12 Speaker 2: yeah, there's your biggest, 49:13 Speaker 2: there's some studies here, 9 to 11% average body weight loss over 24 weeks. You can see this clinical weight loss in this trial here. What 49:23 Speaker 2: dosing 49:25 Speaker 2: is, I don't know, daily 2 49:28 Speaker 2: 50 49:29 Speaker 2: micrograms 49:30 Speaker 2: to 500 micrograms on the high end, 1000 49:34 Speaker 2: micrograms. So this is what you're seeing. 49:36 Speaker 2: Here's 49:37 Speaker 2: for the 2 50 micrograms, 49:39 Speaker 2: 500 micrograms and 1000 micrograms. 49:42 Speaker 2: Okay. 49:44 Speaker 0: But it's good. I mean, it's, it's definitely a good compound. So 49:48 Speaker 2: again, 49:51 Speaker 2: okay. GLP-1s): 49:52 Speaker 2: here is good. Let's talk about when, 49:55 Speaker 2: what types of populations, 49:57 Speaker 2: etcetera, should take this. So those of you who ask us, Hey, I'm on GLP-one and I'm going to stop taking it. 50:04 Speaker 2: This 50:05 Speaker 2: is a perfect, like wean down alternative. 50:09 Speaker 2: Okay. You want to give yourself a break, right? The GLP-one 50:12 Speaker 2: is going to 50:13 Speaker 2: well, work it works differently. So I guess in JD did ask me this, like, why 50:19 Speaker 2: so the GLP-1s 50:20 Speaker 2: are, well, Retta, let's take Retta because that's what everybody should be taking here. It 50:25 Speaker 2: also has that same same mechanism 50:28 Speaker 2: in your brain to make you not be looking for a dopamine spike. Okay? I think Tesofensine is stronger than the GLP-1s, 50:36 Speaker 2: but GLP-1s do give you that also. That's why you see this. Well, my girlfriend's sending me TikTok videos of people who like, 50:42 Speaker 2: I don't love anybody. I have none of those numb because I take the bread out. No, I think it's just an excuse. It's like, maybe that made you happen this much. There you go. Anyway, 50:52 Speaker 2: so it does have that ability. Okay. But the GLP-1s also, they are the ones that make your stomach feel full really fast because they slow your digestion. This does not do that. It's not you're gonna eat you're gonna be able to eat, but you're not eating 51:06 Speaker 2: for happiness spike. Right? 51:10 Speaker 2: It so 51:11 Speaker 2: so that it's not gonna reduce your your overall hunger. And also the GLP-1s when you're not eating food, so during those phases that you don't eat, it actually 51:20 Speaker 2: shoots up a whole bunch of glucose to your brain and keeps your brain still working, 51:25 Speaker 2: not hangry and working at a high level. Tensifencine is not going to do that. You need food. It's going make your brain your dopamine better, 51:33 Speaker 2: but that only works so much. You have no blood sugar 51:36 Speaker 2: no food there to fuel your brain, it's, you're still going to get hangry. You still need to eat some food, but I guess, I don't know. 51:43 Speaker 2: Generally it's the sweets and sugar and all that crap that makes people fat and not the substantive food, 51:50 Speaker 2: you know? Another, and why also helps you lose weight is those of anybody who, if you're not a very active person, 51:56 Speaker 2: you're a couch potato, you start taking this, you start getting more motivated shit. 52:01 Speaker 2: Instead of sitting on the couch all night tonight, think I'm gonna go fold laundry. I'm gonna go for a walk, maybe. You do that on a consistent basis. Yeah. You're going to start burning more calories and, you know, in object in motion tends to stay in motion. 52:13 Speaker 2: Object at rest tends to stay at rest. Okay. 52:17 Speaker 2: Domino effect either way. 52:19 Speaker 2: Will help you trend 52:21 Speaker 2: the other way. Yeah. I noticed it right away. Yep. It did. It freaking works, dude. I love it. So guys, I don't know. I love it. I think I'd be taking it and I like it. I did. I used to love taking naps now. 52:32 Speaker 2: Yes, I'm busier, but 52:34 Speaker 2: doesn't 52:35 Speaker 0: sound appealing. Totally agree with that. Taken I've the last 3 weeks. I'm not, I'm a pro nap person, but I've not been needing naps. 52:42 Speaker 0: That's been great. So that's what you're saying recommended, 52:45 Speaker 0: 8 weeks on and, 4 weeks off. I don't know. Yes, yes. As a 52:51 Speaker 2: conservative to be conservative, which is kind of what I want to tell people, I do as I say, and as I do, like I have, if so here's the, because of the serotonin I noticed, so I, I, there are withdrawals from my SSRI. 53:05 Speaker 2: So 53:06 Speaker 2: 1 of them being the brain zaps. If anybody knows what I'm talking about, then they know what I'm talking about. Your brain just kind of goes, you 53:12 Speaker 2: almost feel like you blacked out for 0.25 of a 2nd. That 53:17 Speaker 2: happens when you, when you stop all of a sudden taking SSRIs. 53:20 Speaker 2: Also, if you are naturally depressed and you start taking them, cool, your body's not 53:24 Speaker 2: keeping as much serotonin, your brain doesn't, so you will feel a bit depressed. 53:28 Speaker 2: So therefore, 53:29 Speaker 2: with this, if you take this long term, there will be some withdrawal symptoms. Probably those that I just texted. So So either if you're going to take it long term, don't stop or be smart. If you do stop, you need to slowly wean yourself down. So this is another, like you said, this is another something to take, but 53:47 Speaker 2: this is just for information to give you guys and make an informed decision. 53:51 Speaker 2: Personally, 53:53 Speaker 2: I actually have taken, I was on this for about 4 months and then stopped for 2 weeks 53:59 Speaker 2: on accident 54:00 Speaker 2: and felt no withdrawal symptoms. And I was actually quite surprised. I thought I would, withdrawal symptoms aren't bad though. I mean, even like serotonin, 54:07 Speaker 2: get the brain zaps. I don't know. I think it's kind of fun anyway. The 54:12 Speaker 2: depression sucks if you're depressed though, because depression sucks. 54:16 Speaker 0: Depression in my opinion can be cured, but just get moving. 54:19 Speaker 0: Yeah. 54:20 Speaker 2: But that's easier said than done. It's like when you're actually depressed, 54:23 Speaker 2: you know, fuck if I can get up that wouldn't fix this probably, but I'm not getting up. 54:30 Speaker 0: I hear you. I've never, then 54:32 Speaker 2: when you're forced to, 54:34 Speaker 2: that's how, again, 54:36 Speaker 2: motion, object motion tends to stay in motion. It gets a little bit better and better and better. You gotta just, you gotta lean on I've that moment. Been down the hill, baby. Yeah. But you're right. You're right. Always the base of diet, 54:47 Speaker 0: nutrition. 54:48 Speaker 0: Gosh, these things both, but like, man, you got to have that stuff in line. You're sitting, coming right off the couch, these things aren't going to shine. Yeah. 54:55 Speaker 0: That. And 54:56 Speaker 2: use them. Yes. So dosing chart 54:59 Speaker 2: again, I did say, so 55:03 Speaker 2: 2 50 micrograms is your low dose, lowest effective dose. It may or may not even be effective. 55:09 Speaker 2: 500 micrograms. Here's my suggested take these in the 1st 0.5 of the day. Okay. It's going to give you energy. It's not really like heart beating, 55:17 Speaker 2: extra fast energy, but you still don't want take it before bed and try to sleep. You'd probably be like, damn, I really want to go like do some stuff. 55:24 Speaker 2: Create something. You won't sleep. 55:26 Speaker 2: 1000 micrograms is advanced. Personally, I am taking 1000 micrograms and taking 2 pills a day and I just take them in the morning. Yep. 55:33 Speaker 2: Take them in the morning together. 55:35 Speaker 2: This is just a kind of a titration phase. So here's, here's an example of how somebody, if they wanted to titrate up, 55:43 Speaker 2: that's how you can do it. And you know, Hey, everybody's brain chemistry is different. So if this is turning bad on you, like JD's 1st experience, then maybe you don't take it. Yeah. Okay. Timing morning 55:54 Speaker 2: with food optional 55:57 Speaker 2: and the important parts of insomnia, 56:02 Speaker 2: anxiety, dry 56:04 Speaker 2: mouth, that may happen. I have had that. I haven't noticed mild heart rate increase. I've never had that. So here's the things not to do. 56:13 Speaker 2: Take other 56:15 Speaker 2: SSRIs 56:16 Speaker 2: or NRIs or MAO eyes. Okay? So you just don't wanna double up on the drug. So you don't wanna be taking Wellbutrin or Zoloft 56:23 Speaker 2: and then also add in Tesofensine. 56:27 Speaker 2: Monitor your blood pressure. 56:30 Speaker 2: Don't have uncontrolled hypertension. So don't be just stressed out of your effing mind. That's 56:36 Speaker 2: a general rule. Shouldn't do that anyway. Okay. 56:40 Speaker 2: And if you have a history of psychiatric problems, 56:43 Speaker 2: well, anxiety disorders bipolar, like this is a brain med. This might 56:48 Speaker 2: not work right as you want it to, or might do something weird with your preexisting condition. So that one's just like, duh. I mean, you also- 56:55 Speaker 0: Use your brain. Yeah. Don't wanna, I don't know, jump off a building with bipolar 57:01 Speaker 2: or any other way. 57:03 Speaker 2: Stimulant interactions. 57:05 Speaker 2: Reduce caffeine. You're right. Don't take with modafinil. 57:08 Speaker 2: To be honest, like I'm drinking coffee right now. 57:11 Speaker 2: The worry there is that it's just a little bit too, like, a stimulant 57:15 Speaker 2: overload, 57:16 Speaker 2: and it could kind of burn out fray those stimulant receptors. 57:21 Speaker 2: And I don't think it's not dangerous, but it may 57:24 Speaker 2: not be necessary to actually drink 57:27 Speaker 2: those extra cups of coffee. 57:29 Speaker 2: Unnecessary. 57:31 Speaker 2: That's about it. That's all that the real that I real kind of worries are regular, you know, shit, regular blood tests, 57:39 Speaker 2: like everything else that we ever talk about. It's probably a good idea. You're 57:44 Speaker 2: anxiety ridden and like, that's 1 of your verts and maybe just go slow, start if you're going to try it, just really low and make sure that you can do it. Then you can always go up. Yeah, for sure. So, right. If you have anxiety, this is going to give you a bit more energy. So if you're very sensitive to having anxiety with a cup of coffee, this may not be the thing for you. Hail, it might be though. 58:05 Speaker 2: I don't know. So there's Tesofensine, 58:09 Speaker 2: We're telling you about our experience and that's it and telling you what we know. We are not doctors and not the smartest people in the world and do not know anything. So don't listen to anything we say if you don't want to. 58:20 Speaker 2: We're just gonna tell you what we know and what we know from personal experience. 58:25 Speaker 0: And join 58:26 Speaker 0: school. 58:27 Speaker 0: Jump out of school. It's going great. People are loving it. We got a lot of stuff coming. We're gonna be adding some stuff coming 58:34 Speaker 0: probably next week where 58:36 Speaker 0: Will and I will be doing hopefully like a Zoom call a week for the people that are joining the VIP. 58:42 Speaker 0: So we're going to do some add ons. Obviously, that's going to cost not a lot. We're going to give discounts on certain things too. 58:50 Speaker 0: Mathematically, 58:51 Speaker 0: you come way ahead, 58:53 Speaker 0: but you have to understand we run a business and we have busy lives and 58:58 Speaker 0: we get a lot of emails and DMs and stuff. Can't answer them all. 59:02 Speaker 0: That's where we're going to answer them. You got to pay a little bit of money and we'll answer them. And we don't think we're special at all. Just, that's how we can make it work. 59:10 Speaker 0: And we're gonna get do some cool stuff. We've dropped some cool stuff already, I think, and we're gonna continue to add, 59:16 Speaker 0: have some guest speakers on for just that group 59:20 Speaker 0: where conversations can be a little bit more direct and deep and you'll be able to probably talk to some of them too. So cool stuff coming down the pike. 59:28 Speaker 0: Yep. 59:30 Speaker 2: Let's go. We've worked, you know, I mean, hell, look, 59:34 Speaker 2: we are providing a good service. So there is a little bit of a fee. If you really want personal 59:39 Speaker 2: service, if you have absolutely like the nitty gritty questions, you 59:43 Speaker 2: may, you may ask and we will give you our best answer. If we don't know it or aren't satisfied, 59:48 Speaker 2: we will, we have lots of professionals that we know that we will get the answer from. Maybe you have them chime in and it costs money because it's a good service and it will be frigging helpful. And there's a lot of value 3 behind it. Yeah. 1:00:00 Speaker 0: So that is coming. Than that, we got a Paul back TR next week. And then we got-1sixteen Two:twenty Sam Borghi. 2 docs next week or not. He's 1:00:08 Speaker 0: not a doctor, but he's a peptide guy, big peptide guy. So he's coming on. And then Doctor. Sam-1.2 1:00:15 Speaker 2: He 1:00:18 Speaker 2: did my hair replacement, but he's also, 1:00:21 Speaker 2: an ER surgeon 1:00:23 Speaker 2: actively doing 1:00:24 Speaker 2: that and has, 1:00:26 Speaker 2: started his own 1:00:30 Speaker 2: orthopedic, 1:00:31 Speaker 2: like peptide practice 1:00:33 Speaker 2: where they are doing like rehabilitation with peptides and then also 1:00:39 Speaker 2: online Rx 1:00:41 Speaker 2: peptide for the FDA approved peptides online called Summer. So he'll tell you about that. So next week, you got 2 people. So he's in it, like talk about, you know, yeah, healing from, well, all types of injuries. He's in big bear right now, think, or he's going to be. He moonlights or does does, like, 24 hours. He's cool, man. Yeah. We'll talk about him. We'll talk to him. He'll be fun. And, 1:01:01 Speaker 0: yeah, stay tuned. That'll be fun. Other than that, that's next week. We will see you guys then. 1:01:07 Speaker 0: Later. Goodbye. Yeah. Good stuff.