Peptide of the Week: GLP-1 Breakdown – Semaglutide vs Tirzepatide vs Retatrutide Peptide of the Week https://peptideoftheweekpod.com/episodes/peptide-of-the-week-glp-1-breakdown-semaglutide-vs-tirzepatide-vs-retatrutide/transcript We are not doctors. The content on this site is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Amounts, timing and cycle lengths below are reported as the named speaker described them. Nothing here is a protocol to follow. --- 0:00 Speaker 0: Chronic migraine: 15 or more headache days a month, each lasting 4 hours or more, can make me feel like a spectator in my own life. Botox, onabotulinum 0:08 Speaker 2: toxin A, prevents headaches in adults with chronic migraine. It's not for those with 14 or fewer headache days a month. It's the number 1 prescribed branded chronic migraine preventive treatment. Prescription Botox is injected by your doctor. Effects of Botox may spread hours to weeks after injection, causing serious symptoms. Alert your doctor right away as difficulty swallowing, speaking, breathing, eye problems, or muscle weakness can be signs of a life threatening condition. Patients with these conditions before injection are at highest risk. Side effects may include allergic reactions, neck and injection site pain, fatigue, and headache. Allergic reactions can include rash, welts, asthma symptoms, and dizziness. Don't receive Botox if there's a skin infection. Tell your doctor your medical history, muscle or nerve conditions, including ALS Lou Gehrig's disease, myasthenia gravis or Lambert Eaton syndrome, and medications, including botulinum toxins, as these may increase the risk of serious side effects. Why wait? Ask your doctor, visit botoxchronicmigraine.com, 0:57 Speaker 0: or call one-eight hundred-44Botox 0:59 Speaker 0: to learn more. 1:01 Speaker 3: Low energy, unfocused, 1:03 Speaker 3: foggy? You might be dehydrated. 1:05 Speaker 3: Whether it's hot yoga, over 100 degree weather, or too much sun. Gator Lite, with a specialized blend of 5 electrolytes, 1:13 Speaker 3: was scientifically designed to help move fluids into the body faster for rapid rehydration. 1:18 Speaker 3: Shop now at retailers nationwide. 1:21 Speaker 3: Lite hydrates faster than water. Is it in you? Symptoms noted are signs of mild to moderate dehydration. 1:27 Speaker 3: Consult a healthcare professional if symptoms persist. 1:38 Speaker 4: Welcome back to the Peptide of the Week Podcast. 1:42 Speaker 4: I am your host, JD Denham, 1:44 Speaker 3: like always across the way, William T. Hawk. What's up? What's up, dude? What up, man? Showing off my 1:53 Speaker 3: hair replacement. Yeah, dude. You never lost your hair. What the hell happened? Yeah. 1:58 Speaker 3: I don't know. So this is everybody. This is what I think I'm 7 weeks 2:03 Speaker 3: out. 2:05 Speaker 3: Good amount of hair here. 2:07 Speaker 3: You know I mean? So, yeah. You're not gonna keep in shape? We'll 2:11 Speaker 3: see. I think I'm gonna let it grow a little bit. I'm gonna keep it short, but I mean, yeah, maybe. Yeah. Maybe. We'll see what happens. I don't know. I did, I guess, realize that it didn't look too bad in a bald head, although I think it looked better 2:24 Speaker 3: when I was a bit, like, more swollen. Oh, yeah. Because like my head isn't round, obviously. It's like long and 2:32 Speaker 3: a shaved head, I think, looks better with somebody who's got like a round head. So when I was, like, swollen, 2:39 Speaker 3: it looked better than Jack Eyes. Whatever. Looked good with bald head. Yeah. Yeah. 2:44 Speaker 4: Well, let's talk about something cool real quick. Man, 2:47 Speaker 4: this whole ride's been crazy. Geez. It was like Will and I were talking about this before, 2:52 Speaker 4: but this whole thing was just kind of like a fluke. Don't even know. 2:56 Speaker 4: Start of this podcast 2:58 Speaker 4: was kind of when we were in Vegas doing some stuff and trying to do some different marketing stuff up there and trying to find a path that we were going to take the business. 3:06 Speaker 4: We 3:07 Speaker 4: sat down 3:09 Speaker 4: in the win and recorded a 10 minute 3:14 Speaker 4: video on BPC-157. 3:16 Speaker 4: And that was kind of the Genesis of the 3:19 Speaker 4: podcast, but we had no clue it was going to turn into podcast. 3:22 Speaker 4: Were just kind of put out some different content on peptides for 3:26 Speaker 4: our Instagram and stuff like that. So it's just truly amazing for what has happened. I mean, we just reached a milestone of 300,000 3:35 Speaker 4: viewers per month, which I didn't know really what that meant until I threw it through JatGBT. 3:40 Speaker 4: I was like, wow, that's actually a pretty big deal. So the cool part of that is like neither of us, that was so not the objective. Like, let's try to make, like do well on a podcast. 3:51 Speaker 4: Was like, let's just talk about stuff that we were going to talk about. Like, you know, if you notice, like some of, we don't really talk about what we do much, like little nuggets here and there, but that wasn't the objective. The objective was to sit down and just 4:04 Speaker 4: try to shine a light on things that 4:07 Speaker 4: we truly believe in. We truly 4:09 Speaker 4: believe are going to change the world and really help people get back to health. The world has really stepped away from health. 4:19 Speaker 4: We all, everybody got fat. Everybody got big. Everybody got fat. 4:23 Speaker 4: The sugar companies did that lobby thing in 1977, 4:28 Speaker 4: man, everybody got fat. And then they got fatter once seed oils came and all that stuff. But our goal, you know, we have a lot of goals. 1 of them is to just do our part and to try to make a dent in the world, which is to try to help people get healthy. This podcast was just a blessing. 4:43 Speaker 3: I mean, in less really, just because 4:46 Speaker 3: being healthy 4:48 Speaker 3: is so much more. 4:50 Speaker 3: People are just such better, happier 4:53 Speaker 3: human beings when 4:55 Speaker 3: you are actually working hard and proving to yourself that you can do hard things 5:01 Speaker 3: and 5:02 Speaker 3: saying no to things to food and going, hey. I'm tired. I'm still gonna work out. Right? Yeah. And then looking better and feeling better. Right? Like we always say when I was playing football, hey, man. 5:12 Speaker 3: There's no shame in trying to look good. Right? If you look good, you feel good. If you feel good, you play good. So, 5:19 Speaker 3: I don't know, it just does a miracle. Like, I heard somebody, 5:23 Speaker 3: 1 of these motivational speakers who admittedly is kind of an asshole, but I did like 1 thing that he said, he said, you know, if you're unhappy, 5:30 Speaker 3: right, 5:32 Speaker 3: go get a 6 pack. 5:34 Speaker 3: And it's not the fact that you just go, 6 pack, now I'm happy because look, right? No, because of the entire journey to 5:43 Speaker 3: get there, right? You 5:45 Speaker 3: learn a lot about yourself, you put a whole bunch of hard work in and you're proud of yourself 5:50 Speaker 3: and you did a bunch of stuff you didn't think you could do because that's hard to get a 6 pack. And by the end of that journey, you're going be happy. 2 5:58 Speaker 4: Until you become during that through the journey. Yeah. A lot of people don't know that. It's funny, I've seen a meme that made me think what you're just talking about. I don't know if you've ever seen it, it's 3 dudes stepping on podiums, 1st, 2nd, and 3rd, and it only shows that part, the guy on 1st, you know, on top. And under that, it shows 6:16 Speaker 4: failures 6:17 Speaker 4: and discipline and all these things that it took to get there. But everybody just sees the dude on top and like, well, he's just gifted. 6:25 Speaker 4: Worked his ass off for 20 years, man. Know I mean? But everybody's like, wow. Yeah. 6:30 Speaker 3: You see somebody who's like being successful, right? And everybody's like, look at him 6:35 Speaker 3: or even, yeah, or in business, right? Like, oh, look at him. He's greedy. He's not like giving any me any of his money. He just like, oh, what they don't see is the, you know, 5AM wake ups and 6:46 Speaker 3: going home and saying, you know, no to family and working their ass off from being tired all the time and 6:52 Speaker 3: all that like anxiety and stress and 10 years of work, 6:57 Speaker 3: you know, as learning whatever the business is right before they actually decided or was able to make any money at it. 7:04 Speaker 4: That dude. I just did a podcast and I was talking about that, which is when I everything's pre and post sober for 7:11 Speaker 4: you too, right? Where, like when got 7:15 Speaker 4: sober 7:16 Speaker 4: and I got, it took me a year to do the whole, you know, get well job and all that stuff. When I got back into the mortgage industry, I'm a different man. I really am a different man. I wanted to be a student of my craft. I became a mortgage banker. I had no clue where money came from, how it worked, how banking worked, none. I thought everything. 7:33 Speaker 4: So 7:34 Speaker 4: I studied it. I just dug into it. I was so curious and I started reading and reading and reading and reading. I mean, I thought the Federal Reserve was federal, so I was blown away by just that. And then I was like, this is cropped, man. And I was like so frustrated. 7:48 Speaker 4: But I learned and I learned and what I learned by that, and the point of this is I learned how to invest and I learned how to put money because I knew kind of how money worked. I knew how to sell better in mortgages because I knew how money worked. 8:02 Speaker 4: I became a student of my craft 8:04 Speaker 4: and it's not about the money I made because of it. It's about the journey, like you just said. That has served me so well, just studying. 8:12 Speaker 4: The wealthiest people 8:14 Speaker 4: never stopped learning. Yeah, absolutely. 8:16 Speaker 3: The best. Right. I guess there's some quote and I'm going to butcher it, but I 8:23 Speaker 3: don't know. Yeah, there's nothing more dangerous or something than somebody who 8:26 Speaker 3: already knows it, 8:28 Speaker 3: knows they knows things, right? And like the more you know, the 8:31 Speaker 3: less you realize you know. And 8:35 Speaker 3: so, yeah. 8:38 Speaker 3: The 1 thing that I don't want to, I'll butcher the quote. Carry on. Go ahead. 8:42 Speaker 4: Want to read this Jedi status. I use this all the time, it's 8:46 Speaker 4: so perfectly said, 8:48 Speaker 4: if you say you're not going to eat chocolate cake and you go out to dinner and all your friends are going to be, have a bite, but you made a commitment and you don't take a bite, it's not about chocolate cake, enjoy it. But if you say you are not going to eat it and you keep your word, you walk out so freaking empowered. 9:05 Speaker 4: I learned that through sobriety, the empowerment of telling myself no, and it's never stopped. So the people to get your 9:13 Speaker 4: 6 pack, 9:14 Speaker 4: that's just 1 form of a 6 pack. It could be climb Mount Everest is your 6 pack. It's not standing on top. That's like 3 minutes. 9:23 Speaker 4: You worked your ass off for months 9:25 Speaker 4: to say, 3 minutes, I did it, but it's who you came because your whole time for 3 months, turn around, dude, turn around, dude. You're cold, you're freezing. But you push through that stuff, man. Oh man, you just, I love that stuff. Yeah. You know, I guess we only learned these things through 9:42 Speaker 3: living in trial and error, Getting 9:47 Speaker 3: sober, 9:48 Speaker 3: right? And we all have, well, we should, I suppose have sponsors. And 1 of my 9:54 Speaker 3: tasks was to identify a principle that I live my life by, right, that has served me wrong, 10:02 Speaker 3: you know, that has not been helpful, right? But since I was a little kid, it kind of was like a mantra almost, 10:08 Speaker 3: I thought of and that was like 10:11 Speaker 3: kind of I have to be the best at things. 10:14 Speaker 3: And the problem there is like, that would make me just like not try at things if I wasn't going to win. You know what I mean? Like, not even enter and give up too early, but so I could save face. You know? And I listened to 10:29 Speaker 3: this is a NFL football player, and he said, from a little kid, dude, I just looked for ways I could just fail. I could jump in somewhere way over my head, 10:39 Speaker 3: right, 10:40 Speaker 3: and get my ass kicked, basically. Right? And that is awesome. That's a great way to live, right, as opposed to kind of the way that I and you know, I'm not perfect, right? I have learned these things over life, right, where where, 10:53 Speaker 3: yeah, I didn't want to go in there and then just get beat up. Right? I didn't want to go play with a bunch of older kids and then just look like a fool. Right? 11:01 Speaker 3: He did. That's what he did his whole life, and that's why he became Like an 11:05 Speaker 3: all pro in the NFL. That's right. So with River at home, right, dude, he and he's kind of the same. He's 11:12 Speaker 3: he always wants to look good and always be the best, and I try to just instill in him. Like, dude, failure is good. Go fail. 11:20 Speaker 3: Goal should be just 11:22 Speaker 3: try and fail. Okay? Please try and fail. I also didn't want to look bad. I didn't want to give 11:26 Speaker 3: everything I had and then fail. You know what I'm saying? That's embarrassing. But 11:32 Speaker 4: really, once you get over that embarrassing factor, that's how you grow. Oh yeah. Is what it is. Well, true liberation is not giving a shit about anybody's opinion about your own. Know, I always say I'm in competition with me yesterday. That's it. You know what I mean? I have a buddy at the gym that the 11:49 Speaker 4: last few weeks he had, in a few months, he's busted his ass, busted his ass. I saw how disciplined he is with diet. I've just seen the diets he had to go through different stages and he won. 12:01 Speaker 4: And 12:02 Speaker 4: I was so freaking stoked for him, dude. And like, I just saw him on there and my dude, he busted his ass and I was just thinking, man, how much work can I just, I saw it, saw it? I saw him say no to himself thousands of times. Right? And anyways, 12:17 Speaker 4: it's a bummer that a lot of people don't want to see people win, but I thought it was rad and I thought I'd love hard work, man. So good stuff, dude. But yeah, so 300,000 12:26 Speaker 4: viewers. Thank you all. You Aussies are holding the tab, man. You guys seem to love us out there. That would be cool to maybe 1 day if if if the, 12:35 Speaker 4: you know, the seas parted, we'd go out to Australia and do a live Australia. I 12:41 Speaker 3: heard Australians. 12:43 Speaker 4: Do hear that, Aussies? 12:45 Speaker 4: Down under. We go down under and do a pepatide of the week. 12:49 Speaker 4: Maybe it's coming. We always want to enhance this podcast again. It just kind of happened. It just started. 12:56 Speaker 4: As you can see, if you watch from the very beginning, go look at something. It's changed. But our goal in life, and that's why Will and I get along so well 13:04 Speaker 4: is just to keep getting better, keep giving the experience better, just keep 13:09 Speaker 4: growing and doing better, doing more. And it's not about tangible stuff. It's about just doing more because we are supposed to evolve and grow and do more and help people. So what it's about. So that's the goal. So today's a good 1 13:23 Speaker 4: is the infamous GLP-1S 13:26 Speaker 4: Semaglutide, 13:27 Speaker 4: Juzepatide, and the infamous Retrutide. Retrutide. 13:32 Speaker 4: So we'll jump in and let's talk about it, man. Everybody loves them. 13:36 Speaker 4: Does anybody, know what semaglutide is anymore? Yeah, no doubt. Sucker 13:41 Speaker 4: fell off the wayside, even tirzepatide's kind of dying by the wayside, but I guess doctors are prescribing it. Right. Well, it's still those 2 are still the FDA approved. Didn't have some long data and 13:52 Speaker 3: Yes. Not a lot of data. 13:54 Speaker 3: Okay. So yes, folks, we have some technology 13:59 Speaker 3: that we'll go through. So 14:02 Speaker 3: yes, we're talking about semaglutide, tirzepatide, 14:04 Speaker 3: and RET. 1st thing is 14:08 Speaker 3: the 14:09 Speaker 3: receptors. 14:10 Speaker 3: What are they? Okay. 14:12 Speaker 3: 1st things 1st is the GLP-one 14:15 Speaker 3: receptor. What these all have in common. 14:18 Speaker 3: We're going to kind of talk about 14:20 Speaker 3: what the 3 receptors are, okay, than the actual drugs specifically. So 1st things 1st, GLP-one is a glucagon like peptide-one. 14:29 Speaker 3: The interesting part is this is a natural occurring 14:34 Speaker 3: receptor in our body. How 14:37 Speaker 3: it actually works 14:38 Speaker 3: is when we eat a meal, we 14:42 Speaker 3: once we get full, 14:44 Speaker 3: that receptor then gets lit up and it only naturally lights up for about 5 to 10 minutes, okay? That's that feeling of just, you just are full and you've kind of and your brain is happy. It wants nothing more. It wants no more food. It wants nothing else. It doesn't need any other happiness, right? It doesn't need 15:03 Speaker 3: sex or working out or anything like that. No chocolate Satiated, 15:08 Speaker 3: your stomach is actually is full, right? Your body is also producing a whole bunch of insulin to combat 15:16 Speaker 3: all that food you ate so you don't have like a big sugar spike. Okay? So the insulin is pushing out to 15:23 Speaker 3: keep down any sugar spikes. So that's what's happening naturally, 5 to 10 minutes maximum. Okay? 15:31 Speaker 3: That 15:32 Speaker 3: is our native GLP-one. That's how that thing works. Now 15:36 Speaker 3: the drugs, right? The synthetic GLP-one receptor, the difference basically is with these, these guys have made a synthetic GLP-one receptor that is resistant to the breakdown. 15:48 Speaker 3: So it is designed now to last 7 days. So you should that feeling that we just described 15:54 Speaker 3: is gonna go now for 7 days. Is insane. 15:58 Speaker 3: Of 5 to 10 minutes. So you get the brain signaling, right, targets the hypothalamus 16:03 Speaker 3: to increase satiate 16:06 Speaker 3: satiety. You feel full, 16:08 Speaker 3: your brain feels full, gastric 16:11 Speaker 3: emptying, I guess I'm skipping around, but your stomach actually 16:15 Speaker 3: processes food slower. Okay, so you actually are fuller. 16:20 Speaker 3: Less reward seeking. People have noticed they're starting to use these GLPs, like even in addiction, 16:25 Speaker 3: because 16:27 Speaker 3: your brain is not looking for like a dopamine. I'm good. Right? You're just not look you're good. You're happy. You're not looking for sugar to make you happy. Yeah. 16:36 Speaker 3: And insulin secretion, okay, the cool thing about this, it is cutting it is lowering 16:42 Speaker 3: your sugar, pulling the blood or I mean, pulling the sugar out of your blood, which is gonna end up storing and making you fat, right, and pushing nutrients into your muscles, okay, to save that sugar as glycogen 16:54 Speaker 3: to actually use when you're actually using your muscle later, okay, so it's not converting to fat. 17:01 Speaker 3: So there's what the GLP-one 17:03 Speaker 3: receptor does. Oh yeah. And it makes you just all alone when synthetically 17:09 Speaker 3: agonized makes you extremely nauseous. Yeah. 17:12 Speaker 4: Well, so like to just simplify all that, it tells your brain, am full, do not eat. Do not 17:19 Speaker 4: eat. I'm full. A lot of people that have taken it, no, you'd like, they do not eat. And the thing is when you're taking 17:26 Speaker 3: this, 17:27 Speaker 3: your body's pushing a whole bunch of insulin, 17:30 Speaker 3: actually, but you don't have a bunch of food in here, right? Because it's a fake, it's a fake agonism. 17:35 Speaker 3: So your body is going, all right, let's push insulin out, but there really is no food. And therefore it's just really like lowering your blood, moderating your blood sugar so it's really healthy. So your body 17:45 Speaker 2: burns fat 17:48 Speaker 3: because there's no sugar to use as energy. 17:52 Speaker 3: All right. Your GIP, 17:54 Speaker 3: the glucose dependent insulinotropic 17:56 Speaker 3: polytectin. 17:57 Speaker 3: There's a mouthful. 18:00 Speaker 3: So number 1 thing that it does, 18:02 Speaker 3: well, the number 1 thing it does is anti nausea, right? It makes, 18:06 Speaker 3: when coupled with that GLP-one, 18:09 Speaker 3: it takes a lot of the nausea away, depending 18:12 Speaker 3: on how 18:13 Speaker 3: much this GIP is activated. But it also amplifies 18:18 Speaker 3: the GLP-one effect. 18:20 Speaker 3: So, 18:21 Speaker 3: amplifies there improves 18:23 Speaker 3: your insulin That insulin is just going to work a whole bunch better and a bunch more efficient and helps with nutrient partitioning. It's actually taking amino acids, 18:32 Speaker 3: shoving them into your muscles 18:35 Speaker 3: and prioritizing 18:37 Speaker 3: your body to burn fat 18:39 Speaker 3: instead of any sugar, there, well, there really isn't much sugar in the real case. If you're taking, 18:45 Speaker 3: Trizepatide, you're not eating a bunch of food. Okay. So, 18:49 Speaker 3: yeah, I don't know. 18:51 Speaker 3: That is what that GIP 18:54 Speaker 3: does. 18:55 Speaker 4: Next. It takes your food though, and it's going to choose the fat. Instead 19:00 Speaker 4: of choosing the glucose, 19:02 Speaker 4: sugar, 19:04 Speaker 4: which most of us, that's the 1st thing your 19:07 Speaker 4: body goes towards is the glucose, but it goes towards the fat. So that's 1 of the huge things. It's kind of like you're in ketosis. Yeah, right. It does kind of make you as if you were in ketosis. Then our last 1, right, which only 19:20 Speaker 3: Reta has is the glucagon receptor, 19:22 Speaker 3: AKA 19:24 Speaker 3: GCG. 19:25 Speaker 3: Okay? 19:26 Speaker 3: Number 1, this is finally going to boost your metabolic rate. So your BMR, your basal metabolic rate, this is going to just make you burn more calories all day long. It's going to promote lipolysis. 19:36 Speaker 3: Lipolysis means fat burning. Drives 19:39 Speaker 3: a breakdown of stored body fat for energy. It's basically like peeling fat off of you and burning it for energy. 19:46 Speaker 3: It is going to increase heart rates ever so slightly and increase kind of body temp, AKA 19:51 Speaker 3: thermogenesis, 19:52 Speaker 3: which just 19:54 Speaker 3: makes more calorie burning. 19:56 Speaker 3: And the cool thing is like, we know plateau prevention. So we know that our bodies are designed because we're cavemen, right? It works as if we're cavemen. And in the wintertime when food is scarce 20:09 Speaker 3: and we don't eat that many calories, our metabolism is designed to lower down to the amount of calories that we're actually eating so we don't burn all of our tissue off then freeze and starve to death, right? 20:21 Speaker 3: You're not going to be eating as much food, 20:25 Speaker 3: but what Retta does or the glucagon portion of Retta is it makes your metabolism not slow down to that lower calorie intake. It keeps your 20:36 Speaker 4: body burning calories and fast and therefore preventing any plateaus. Yeah. Let's stop there for a 2nd because you said it's going to help your body burn more calories. That is freaking huge. 20:47 Speaker 3: Rad. Yep. Yep. Then 20:49 Speaker 3: we can talk, so there's, those are basically just kind of what the synthetic receptors 20:54 Speaker 3: are doing. 20:55 Speaker 3: Now we actually can talk about them specifically. 20:59 Speaker 3: So Semaglutide, 21:00 Speaker 3: okay? All it 21:02 Speaker 3: does is activate these GLP-one 21:05 Speaker 3: receptor. Okay. It's also known as the brand name's Wegovy Ozempic, 21:09 Speaker 3: GLP-1S 21:11 Speaker 3: or 21:12 Speaker 3: Bronze-one. 21:13 Speaker 3: Okay. These are some names that it is going by out there. 21:17 Speaker 3: We have a picture of a person here looking kind of sickly, right? Nauseous as hell. 21:24 Speaker 3: Not much muscle, not much fat, but 21:27 Speaker 3: not very happy. 21:29 Speaker 0: Okay? Chronic migraine, 15 or more headache days a month, each lasting 4 hours or more, can make me feel like a spectator in my own life. Botox, onabotulinum 21:38 Speaker 1: toxin A, prevents headaches in adults with chronic migraine. It's not for those with 14 or fewer headache days a month. It's the number 1 prescribed branded chronic migraine preventive treatment. 21:47 Speaker 2: Prescription Botox is injected by your doctor. Effects of Botox may spread hours to weeks after injection, causing serious symptoms. Alert your doctor right away as difficulty swallowing, speaking, breathing, eye problems, or muscle weakness can be signs of a life threatening condition. Patients with these conditions before injection are at highest risk. Side effects may include allergic reactions, neck and injection site pain, fatigue, and headache. Allergic reactions can include rash, welts, asthma symptoms, and dizziness. Don't receive Botox if there's a skin infection. Tell your doctor your medical history, muscle or nerve conditions 22:18 Speaker 2: syndrome, and medications, including botulinum toxins, as these may increase the risk of serious side effects. 22:24 Speaker 0: Why wait? Ask your doctor, visit botoxchronicmigraine.com, 22:27 Speaker 0: or call one-eight hundred-four-four BOTOX to learn more. 22:30 Speaker 3: Because you lose But you're getting skinny. Because you're getting skinny. I'm skinny, but I feel like shit. Shit. The important part here is, so this is what is kind of interesting and unique. So semaglutide 22:42 Speaker 3: is a full GLP-one agonist, okay? So that means that it activates that GLP-one receptor 22:49 Speaker 3: about equal to our native 22:53 Speaker 3: GLP-one 22:53 Speaker 3: receptor being fully activated. Okay? So it's kind of a 1 to 1 ratio. 22:58 Speaker 3: These are approximations, 23:00 Speaker 3: folks. 23:02 Speaker 3: And so 23:03 Speaker 3: it activates that 100%. 23:05 Speaker 3: You're getting all the effects of just that GLP-one, 23:08 Speaker 3: but for 7 days. Okay? No appetite, heavy nausea, 23:12 Speaker 3: fat and muscle indiscriminately 23:14 Speaker 3: lost, right? In these studies, 23:17 Speaker 3: they have found 15 to 17 percent is the mean weight loss, which is amazing. That's a lot. That's a lot. We know that. I mean, there's- Well, let's focus. You stroll 23:26 Speaker 4: right past that though. Heavy nausea. 23:28 Speaker 4: Like 23:30 Speaker 4: you have so many people that have tried this and they, man, they hate it. And they, a lot of people abort because they can't get through it. But 23:37 Speaker 3: the ones that stay on and get through it, they just don't eat. And a lot of people just get used to feeling like shit. Think that I remember when there's a- I would imagine your body kind of adapts. It does. It kind of adapts. I mean, absolutely. So when you 1st do it, you're going to be way more nauseated that gets better, but still 23:52 Speaker 3: you don't quite realize after a while 23:56 Speaker 3: that how bad you felt Yeah, yeah. Until you start 23:59 Speaker 3: different. Right? 24:00 Speaker 3: And so there's your Semaglutide. 24:03 Speaker 3: Next is Tirzepatide, 24:05 Speaker 3: AKA Zepbound Mounjaro's, your brand names you're gonna see out there or AKA GLP-2T 24:11 Speaker 3: or SILVER-two. 24:12 Speaker 3: Okay? So it activates your GLP-one 24:15 Speaker 3: and GIP. 24:17 Speaker 3: But notice here, so it is a partial GLP-one 24:22 Speaker 3: agonist. 24:23 Speaker 3: And this is an approximation again, but it's about 5 times weaker 24:27 Speaker 3: than our native 24:29 Speaker 3: GLP-one, 24:30 Speaker 3: right? Semaglutide was full, was 1 to 1. This is about a 5 24:37 Speaker 3: to 1 ratio of activation. 24:40 Speaker 3: The GIP, 24:41 Speaker 3: it is a 1 to 1. It's a full GIP 24:44 Speaker 3: agonist. 24:46 Speaker 3: Now, 24:47 Speaker 3: so you're getting a little bit, but guess what? When we add in GIP on top of the GLP-one, 24:52 Speaker 3: it actually 24:54 Speaker 3: increases this a lot. So it's kind of not fair to say, know, people say, well, wait a minute, Tirzepatide 25:00 Speaker 3: does 25:01 Speaker 3: really stop 25:02 Speaker 3: my hunger. You're right. You're right. It's because this is actually 25:06 Speaker 3: synergistic and this goes up. Yeah. They work like in tandem. They work really well. And in fact, really, if you actually look into just, you were to take, not have a 25:17 Speaker 4: You're screwed. 25:18 Speaker 3: GIP, like the whole, GLP alone, basically his job is to store fat. Everything 25:23 Speaker 3: about it says that you're going to gain weight. So this is always a tough explanation. 25:29 Speaker 3: Why is it, but it's doing the opposite. It is it's, 25:33 Speaker 3: but it enhances the hell out the GLP-1. So it enhances the hell out of the GLP-one. 25:37 Speaker 3: Okay. You get 1 less nausea, but not, 25:40 Speaker 4: not no nausea. Right? I That's still know. Kind of subjective because some people just with weak stomachs, man, you still feel nausea, but like night and day from, I think Semaglutide 25:49 Speaker 4: and 25:50 Speaker 4: then Tirzepatide 25:51 Speaker 4: leaps and bounds. Right. I would say leaps 25:54 Speaker 3: and bounds better. And that's where I get a lot of feedback from people being like, holy shit. I didn't know how bad I felt that I got used to feeling, 26:04 Speaker 3: until I switched over to Zepatide. So you're 26:08 Speaker 3: going to get a lot less muscle catabolism because this is really like enhancing 26:14 Speaker 3: your insulin sensitivity. Insulin is going to do a whole lot better 26:17 Speaker 3: job at what it does. Therefore, 26:20 Speaker 3: pushing- 26:22 Speaker 4: Nutrition nutrients 26:24 Speaker 3: into muscles 26:25 Speaker 3: and using fat Yeah, for 26:29 Speaker 4: that's the big thing is like the semaglutide 26:31 Speaker 4: didn't do any of that. So when you add in these 2 together, it's gonna at least when you eat, it's gonna take that food and put them to the right places. It's gonna shove the glucose into the muscle and it's going to tell your body to burn fat. Like I said, kind of similar to like somebody on ketosis. Yeah. But the problem is people still don't really eat much on 26:50 Speaker 3: Tirzepatide, 26:50 Speaker 3: even though they're not when they get it. 26:52 Speaker 3: They still just really don't eat much. And here's your data, like clinical clinical data of mean weight loss. Right? That's a ton. That is a lot of weed. Then 27:00 Speaker 3: finally, 27:02 Speaker 3: Retatrutide. 27:03 Speaker 4: Don't don't don't don't. This is a triple agonist. You can see this guy. This is the Reta man. This is it's like kind of iron He man 27:14 Speaker 3: is lean. His brain is active and firing. His heart is is healthy and kind of energized and Firing. He's got muscle 27:23 Speaker 3: and burning in no fat on him. So 27:26 Speaker 3: as far as these activations, 27:28 Speaker 3: this is also a partial GLP-one 27:31 Speaker 3: agonist. Now it's not as low of an agonist as tirzepatide, 27:35 Speaker 3: but it's 27:36 Speaker 3: about twice as strong, about 0.5 27:40 Speaker 3: as strong as our natural native GLP-one. 27:44 Speaker 3: But 27:46 Speaker 3: GIP, it is a full agonist, 27:48 Speaker 3: but it is an extremely full agonist. It's about 8.9, 27:52 Speaker 3: and I say about, 8.9 27:54 Speaker 3: times stronger than our natural GIP. Okay? Now remember, 27:59 Speaker 3: tirzepatide 27:59 Speaker 3: was 28:01 Speaker 3: the same strength, right? This is 28:04 Speaker 3: almost 9 times as strong on the GLP 28:07 Speaker 3: or the GIP. Therefore, the synergy on it, that means this G, everything that happens in the GLP-one goes way up through the roof, but also remember, GIP is responsible for taking away nausea. Okay? And it's 9 times as strong as 9 times less nausea. That is why people are doing Reto like 28:26 Speaker 3: rarely ever, ever, ever have any nausea. 28:30 Speaker 3: You just get your body is so efficient with its insulin use 28:35 Speaker 3: keeping muscle in the air 28:37 Speaker 3: anabolic, 28:39 Speaker 3: the amount of insulin, right? Bodybuilders have been using insulin to grow muscle. Insulin is anabolic straight up. And 28:46 Speaker 3: when you are activating it and making it that efficient, it starts working for you. Then finally, the glucagon, 28:54 Speaker 3: it's about 28:55 Speaker 3: it's about 3 times weaker, but frankly, 28:58 Speaker 3: if this was any stronger on the glucagon, our heart rate would be beating a lot faster and very unhealthy, and it would be dangerous. So you don't want this thing to be at a 1 to 1 ratio activation as our next to our natural 29:11 Speaker 3: glucagon. 29:12 Speaker 3: Okay? I know, JD, you're gonna have a hard time reading this stuff, but I see it actually this far. So, 29:17 Speaker 3: like, you're you have a massively increased BMR, basal metabolic rate. You're just burning a lot more calories. 29:24 Speaker 3: Don't expect fat burning for energy. It's just healing fat off of you for It literally burns fat right off you like butter. Nope. You know, plateau buster, there is going to be really no plateaus and your brain and body are energized. Like I notice 29:39 Speaker 3: frankly that, 29:41 Speaker 3: man, my brain is 29:43 Speaker 3: just stays up and running fast all day long, regardless 29:48 Speaker 3: of any food that I'm eating. Normally get, as I get older, I definitely notice the foods effect on my brain. 29:56 Speaker 3: On Retta, there's no effect. It just stays strong. Now, and here's your mean weight loss, right? About 24 30:03 Speaker 3: amount, 30:04 Speaker 3: weight loss, which is huge, which is like approaching 30:07 Speaker 3: kind of bariatric Melting 30:10 Speaker 4: like you're fat, dude. It's going to basically just break down the glycogen, which is stored carbs, 30:17 Speaker 4: and it's just going to use that fat as fuel. 30:21 Speaker 4: It uses your fat to just 30:23 Speaker 4: burn everything else. Anybody that's taking it man knows what we're talking about. So 30:28 Speaker 3: there you go. That is Reta. Now let me confer for a bit. 30:32 Speaker 3: Here's a little bit of charts. 30:36 Speaker 3: Of everything that we just went over. So to remind everyone 30:41 Speaker 3: GLP, so Semaglutide, 30:42 Speaker 3: right? Strong activation, a 1 to 1 ratio to towards our native GI GLP-one, 30:47 Speaker 3: no GIP, 30:49 Speaker 3: no glucagon. 30:50 Speaker 3: So 1st thing, average weight loss, it's FDA status is approved. And it's been around longer. Tirzepatide 30:56 Speaker 3: remember. So it's a weak agonist of the GLP-one, although it's 31:00 Speaker 3: the GIP enhances that, but 1 to 1 ratio on the GIP 31:05 Speaker 3: generation 2, a little bit more, more weight loss, 31:09 Speaker 3: a little bit more fat loss and less muscle wasting 31:13 Speaker 3: and Reta again, moderate GLB-1I division, but super 31:17 Speaker 3: extreme, right? This is a 1 to 8.9 31:21 Speaker 3: and a moderate glucagon 31:23 Speaker 3: activation, but good enough as much as you really want. Gen 3 percentage and 31:29 Speaker 3: RET is not 31:32 Speaker 3: FDA approved yet. It's in phase 3 of its clinical trials and should have been approved in January, 31:38 Speaker 3: but 31:39 Speaker 3: still waiting. Here we are. Here we are. 31:43 Speaker 4: That's good. So 31:46 Speaker 3: dosages. 31:47 Speaker 3: So I guess the important part let's 1st look at starting. So 31:50 Speaker 3: Semaglutide 31:51 Speaker 3: is a way different dosage than Tirzepatide and Retta. These are pretty dang similar. So Semaglutide starting dose is 0.25 31:58 Speaker 3: mg 32:00 Speaker 3: max dose is 2.4 32:02 Speaker 3: mg. 32:03 Speaker 3: My suggestion, here's what I've done and have 32:07 Speaker 3: told my friends and 32:09 Speaker 3: loved ones is 32:11 Speaker 3: this 1, I know that the manufacturers are saying take it once week, but because the 32:16 Speaker 3: nausea that it presents, 32:18 Speaker 3: I think you need to split this dose up into 2 or 3 times a week. 32:22 Speaker 3: It just stands to reason. If you give yourself a big dose of it, you're going to be way more nauseous. 32:27 Speaker 4: I know. Right, right, right. We've talked about this with nausea, but it's- So I think that starting dose should 32:33 Speaker 3: be 0.25 mg, but I'd split that in 0.5 at least, right? That's why this says 0.125 32:38 Speaker 3: mg, 2 times a week. Okay. And you know, I would say go to 4 weeks. It's really from this point, from the starting point in all these is you just got to listen to your body and make that decision. I would say we only really want to bump up by 32:52 Speaker 3: in 2.5 increments, okay? So this is 0.25. 32:56 Speaker 3: The next bump spot would be the 0.5 weekly total. Then 33:00 Speaker 3: to 0.75 total. All right? Then to 1 total, 33:04 Speaker 3: still splitting twice a week. 33:07 Speaker 3: Tirzepatide 33:08 Speaker 3: starting 2.5 mg, max dose 15 mg. I have seen some people get up here. I generally would say that women settle in about 5 mg, 33:17 Speaker 4: men settle in about 7.5 mg a week. I mean, I know so many people that get it prescribed and they're at 12. 33:25 Speaker 3: Then- 1 bit on a boom. Boom. Yeah. Like we will always 33:28 Speaker 3: just keep building tolerances to all of these. The longer you're on, the more you're going to slow need to bump up. But again, so here's the thing at this top lowest effective dose possible. The goal is not to just bump up as fast as you can. Yeah. A, it's going to kill your wallet 33:42 Speaker 3: and be like, it's not necessary. 33:45 Speaker 3: As little as you can to get the effective dose. So I would switch to Zepatide. I'd go 3 days week. Sorry. And I would take, I'd start off with like 1 mg Monday, Wednesday, Friday. And 33:55 Speaker 3: then your bump up would be to 33:59 Speaker 3: 1.5 mix 34:00 Speaker 3: Monday, Wednesday, Friday. The next thing would be 2 mgs Monday, Wednesday, Friday, 2.5. 34:04 Speaker 3: So, and 34:06 Speaker 3: then read, I frankly, 34:08 Speaker 3: I'd say the same. I think that this, 34:11 Speaker 3: starting dose in the actual literature is a little bit lower 34:15 Speaker 3: and I don't think a max dose is I've never seen anybody get to 10 mg. No, 34:21 Speaker 3: I've just never seen it really necessary. I'd still start off with 1 mg and I would bump up by 0.5 a mg per mg 3 per times a week. 34:30 Speaker 3: That is 3 mg a week. Hey, I know a lot of people who started here and I mean, I'm 1 of them actually who get back down. I like, okay, 34:38 Speaker 3: I think you did too. You did it for 2 weeks and you said, well, week 1, like, I even know if this is doing anything week 2, you say, Oh shit, 34:44 Speaker 3: I need to eat some more food. I 34:47 Speaker 3: gotta lower this thing down. So 34:49 Speaker 3: everybody 34:50 Speaker 3: just needs to, you know, be grown adults and be smart listen to your body. 34:56 Speaker 4: Your buddy at the gym told you to take this. Yeah, don't care. Do not. Don't 35:00 Speaker 4: care. You take, you start off where, you know, at the starting dose and then listen to your body and do what that tells you to do. Okay. And then you have so many people and we've talked about it so much. Have so many people have talked about 1 time a week or microdose 3 times a week. Listen, you're growing up like you just said, figure it out. We 35:19 Speaker 4: have worked with hundreds and hundreds and hundreds of people, friends and whatnot. 35:23 Speaker 4: And 35:24 Speaker 4: this is for hands on experience and this is what we have experienced. 35:28 Speaker 4: We don't pretend to know it all, but we have seen a lot and whatever something reads is not always right because firsthand knowledge is better knowledge in my opinion. But if you want to do it once, do it once for a month and then microdose it the 2nd month, what do you like? Do feel better with? Who cares? Try it. Yeah. I've got a lot of feedback. People who are doing it once a week generally say, Hey, 35:48 Speaker 3: if I do my injection on Monday 35:50 Speaker 3: by about Thursday, 35:52 Speaker 3: it's, I noticed that all the hunger and noise is back. So that 35:58 Speaker 3: is kind of the biggest reason I think that it should be done several, a couple times a week is it just seems, especially in men, because we metabolize things faster. We're just heavier. We burn through things. 36:09 Speaker 3: It seems to last about 0.5 a week, about 4 days. And now you got 3 days of it not really doing much to you. So that's defeating the purpose. 36:18 Speaker 3: Yes, 36:20 Speaker 3: I definitely think 3 days a week. So there it is, I hope. 36:24 Speaker 3: That was a helpful, 36:28 Speaker 3: and this is my personal notes. 36:31 Speaker 4: Winner 36:34 Speaker 3: of the GHRP- 36:35 Speaker 3: would you not? 36:36 Speaker 3: I don't know. 36:38 Speaker 3: So there's some other interesting things. Had my girlfriend told me last night, she said, Hey, 36:44 Speaker 3: I've read a lot of reports saying that Retta 36:48 Speaker 3: is like breaking up relationships, 36:50 Speaker 3: right? It's like, 36:52 Speaker 3: people are falling out of love 36:54 Speaker 3: because they're on Retta. 36:56 Speaker 3: I said, all right. Well, 37:01 Speaker 3: my 37:02 Speaker 3: diagnosis of that is, okay, A, number 1, 37:05 Speaker 3: yes, the GLP-one 37:07 Speaker 3: receptor, when that is going on in renter, it is going on the best as far as food noise, right? Not killing your appetite, let's get to that too. But 37:15 Speaker 3: it's making your brain not look for dopamine spikes. This is why people say, I don't really like ice cream anymore. They eat their ice cream and they go, this isn't really doing it for me. Was 1. Like, it changes your food preference because 37:26 Speaker 3: your brain is not looking for food to make you happy. Now 37:30 Speaker 3: in a relationship, those people who are in a relationship and are unhealthy and are looking to somebody else to complete them, to make them happy about themselves, 37:41 Speaker 3: that's not a good way to do it. But they're realizing, 37:44 Speaker 3: shit, I don't need that. My brain's happy. I'm content. I'm Retatrut, get out of here. I'm on Retatrut, like I don't need you. 37:50 Speaker 3: But actually, I think in a healthy way, you know? We shouldn't be looking at somebody else. Only 37:56 Speaker 3: when I'm with you am I happy? No, 37:58 Speaker 3: they shouldn't complete you. You should be complete. 38:01 Speaker 3: And they should just synergistically enhance you. So there's 1 and 2, I guess another cynical approach is, well, 38:08 Speaker 3: they're probably losing weight and looking better. Feeling better. Feeling better. Shaking that booty 38:13 Speaker 3: at work. And their partner 38:15 Speaker 3: Yeah. 38:16 Speaker 3: Is not, and they're falling out of love and going, You don't want no Twinkies? Yeah, yeah, they're no, I don't. And 38:23 Speaker 3: I'm still fat. I'm going to the gym. And I'm falling 38:27 Speaker 3: out of love with you. 38:29 Speaker 3: True that. Love life. So 38:32 Speaker 3: be careful people. Be careful. The other note is people say, Wait a minute, but if 38:38 Speaker 3: Rebbe 38:40 Speaker 3: activates that GLP-one 38:41 Speaker 3: receptor even stronger 38:43 Speaker 3: than tirzepatide, 38:45 Speaker 3: why do I have more of an appetite? 38:48 Speaker 3: Okay. The answer there is actually pretty easy. It's like, 38:52 Speaker 3: 1st of all, 38:54 Speaker 3: the no appetite is a side effect. It's not the intention of these drugs, right? The food noise and not looking for dopamine spikes, that's the intention of the drug. Yeah. 39:03 Speaker 3: With tirzepatide, 39:04 Speaker 3: you still have some nausea. You just don't really realize it. You're just kind of like, I 39:08 Speaker 3: don't really feel like I'm gonna throw up, but 39:10 Speaker 3: food in my mouth is dry and water doesn't look appealing. Right? That's a side effect. With Retta, 39:19 Speaker 3: you have none of that at all. So you're like, Hey, food does look good, but when I do eat it, 39:23 Speaker 3: I get full really fast. Therefore it just forces perfect 39:27 Speaker 3: small portion eating on you. Really does. 39:32 Speaker 4: That's why- It's really funny. That's how you keep muscle is by eating protein. I have been on it for a while. It's been about a month I've been off and I've been kind of, for the most part, going back to 1 meal a day. 39:43 Speaker 4: And I've done that a lot 39:45 Speaker 4: and throughout even the time when I was on Retta and 39:48 Speaker 4: I wouldn't even finish my meal, which is so rare for me because I'll fast all day. And then like, if I leave food on my plate, that's just so rare for me. Just hasn't happened in so long. Now it's gone and I'm killing it. Like I ate a steak, eggs, tinned shrimp, and like, that's my meal. I'm like, damn, I'm still hungry. It does make a big difference. So let's break that down really quickly for if you're brand new to these GLP-1s 40:10 Speaker 4: and you don't know anything about them. So the Semaglutide, 40:14 Speaker 4: you see a lot of they called it what is it? What was it? All the movie stars, 40:18 Speaker 4: Ozempic face where they lost all the weight. Ozempic ass. Ozempic. Yeah. All the movie stars were taking it and, like, literally withering away. 40:26 Speaker 4: Have you ever seen a tweaker that didn't eat? You know why they look like that? They don't eat. It's not necessarily 40:32 Speaker 4: the the compound. It's the fact when you don't eat, 40:36 Speaker 4: it's so unhealthy, like you're not supposed to eat, so that's why you get your malnutrition 40:42 Speaker 4: So 40:43 Speaker 4: that's Semaglutide. 40:45 Speaker 4: You will lose weight. You will basically, I think, feel like shit, but you will lose weight. Tirzepatide is leaps and bounds like a 100 times better. 40:54 Speaker 4: And where that still, I think comes into place for people that I've kind of talked with and friends and whatnot. 41:01 Speaker 4: I think if someone wants to lose 50 pounds, sometimes they just have a problem with the food. Like, I've 41:07 Speaker 4: suggested at times tirzepatide 41:09 Speaker 4: to start with just because that's a lot of weight to the degree where it'll block more of the food nor is because they need it to stop. Everybody, 41:17 Speaker 4: everything's a little subjective, but that's where, you know, that has been used in my with me helping friends. The 3rd 1 is obviously the king of the castle, 41:26 Speaker 4: which is Retatrutide. 41:27 Speaker 4: Like God gives us hunger for a reason. Like think logically, 41:31 Speaker 4: we don't want to just block that out. We want to eat, we want to enjoy food. So you can enjoy food. You'll just get full. You will. You'll just be like, Ugh. And as Will said, for him it's ice cream. It's for me, it's Diet Coke. I I drink diet Coke. I'm not a retardant. When I'm on the Retatrutide side, I hate diet Coke. It's like, Ugh, 41:50 Speaker 4: I can't stand it. It's so weird, 41:53 Speaker 4: but that's the beauty of it is you keep your muscle, you, you'll eat, you'll enjoy food. You'll just truly get full quicker. And that's the amazing part of it. So what 42:02 Speaker 4: should you take? 42:04 Speaker 4: Always, Retrutide. Yes. 42:06 Speaker 3: There's 2 things that brought to me. Okay. I hear people say, 42:11 Speaker 3: but Semaglutide 42:12 Speaker 3: or all of these things, right? It makes your hair fall out. It makes your eyes not your eyesight not work. Right? Like, it must be really, really bad for you. Right? That's the negative connotation. It's like, 42:23 Speaker 0: okay. So look, dude, the drug does not do that to you. The drug is not like killing you off killing you. Right? 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Go get the Retta. 44:01 Speaker 4: Basically is what he said. Yes, absolutely. 44:04 Speaker 3: Other- 44:05 Speaker 4: Some of the problem that we've seen is 44:07 Speaker 4: people 44:08 Speaker 4: that have started on tirzepatide or even semaglutide. 44:11 Speaker 4: The problem that we've ran into with some friends we've helped is that 44:15 Speaker 4: does block the food quite a bit. So when they do go to the better compound, which is Loretta, 44:20 Speaker 4: get hungry and they're like not used to being hungry. So it's not working. I promise you it's working. It's burning the hell out of your fat. Let it do what it do. And don't you want to enjoy food? You know what I mean? But it's kind of a mine F for the people that start with Tirzepatide. Or people here's 1, and this is common and there's an explanation for it. They were on Retta. Okay, cool. We're getting some results, but for some reason they went on to Tirzepatide 44:45 Speaker 3: and they lost, they had a lot of weight to lose. They lost weight. Then they got back to Reta and now Reta it's like, damn, why isn't it working as well? I need twice as much to get to feel the same. The reason is, like you said, 44:59 Speaker 3: hunger is a survival mechanism. It is built into our DNA, right? Like God made us to have a very strong hunger. That's how we, that's survival, same sex drive, right? This is how the species survives through skipping. And then we got to find a way to eat and 45:15 Speaker 3: procreate. 45:16 Speaker 4: That's true that too. 45:18 Speaker 3: So what you do is now when you're on tirzepatide, 45:21 Speaker 3: you're just killing that, 45:23 Speaker 3: you're stifling that 45:25 Speaker 3: natural 45:26 Speaker 3: urge. And so what's going to happen on a natural urge if it's not getting food, it's gonna increase. Fight for it. So it's gonna fight for it. So your natural survival mechanism is trying to get up there, get up there, then get up there. Then when you switch to a compound that doesn't make you as nauseous, 45:42 Speaker 3: shit, you have just bit yourself in the butt and now you've just made your, that hunger drive surge. 45:48 Speaker 3: And you take something that can't suppress it as much, 45:52 Speaker 3: you start eating more. Now, yes, you have 45:54 Speaker 4: shot yourself in the foot. Interesting. Yeah. And I think let's really talk about the big elephant in the room, which is 46:01 Speaker 4: eat better, 46:02 Speaker 4: get healthy, 46:03 Speaker 4: start working out. Like these things are amazing. And like the cool thing about these GLP-1s, 46:10 Speaker 4: and Will and I talk about it often and even the like healing 46:13 Speaker 4: peptides, 46:14 Speaker 4: the BPC and TB-five 100 and whatnot, 46:17 Speaker 4: those work really fast and they are kind of, we call them kind of somewhat gateway drugs into other peptides, which is a good way to say it because that's where people start because they work so fast, but like other ones like MOTS-1C and you're not going to like have that instant like fix, you know what I mean? So, but the cool thing is they do get people into them, but they're just very different. They work really well, but everything's going to work better. Again, let's be redundant if you're hormonally optimized, 46:44 Speaker 4: if you work out, if you eat a really good diet, these things will blow you. Just burn that fat up, man. It doesn't matter how much weight. Hear people on the show, 46:56 Speaker 4: lost 2 50 pounds. They're 46:58 Speaker 4: not just sitting there, they're working for it too. They 47:01 Speaker 4: are. They're always like, I work out 5 days a week. They're 47:04 Speaker 3: not like, I'm sitting on the couch and losing weight. Well, right. Where the people say, 47:08 Speaker 3: I haven't lost any weight or like the re the Tresapitide isn't working anymore for me. Okay. I need more. Right. And then they get take more. And then like, now it's not working for me anymore. 47:19 Speaker 3: Well, how about this? Not the answer. Isn't more drugs. The answer is change your life. Change your life a bit, get up and move around and work out. Let's start actually trying. 47:30 Speaker 4: Like, let's just let's 47:32 Speaker 4: try. Like logically 47:35 Speaker 4: you're, you know, you want to procreate and you want to eat, right? So 47:38 Speaker 4: we weren't made to sit on a couch 47:41 Speaker 4: and just exist, 47:42 Speaker 3: you know? We were made to move 3 around like, you know, our ancestors ate like what, 3 times a week, lot of times that's why fat was stored. Feast or famine too. Mean, shoot, sometimes it was not at all for a week and then we just had to eat when we got, when we killed something, we had to eat a lot. 47:57 Speaker 3: Mean, you know, yes, if we could 47:59 Speaker 3: all, our ancestors were way healthier. If that brings us to the hormonally awake, why is testosterone low today? Well, guess what? Our ancestors, 48:07 Speaker 3: wherever they shower in the freezing river, 48:10 Speaker 3: 1 that boosts the hell out your testosterone, right? They would kill stuff with their bare hands. And that would, that boost your In the beginning, do hard shit, do hard shit. Yeah. Like I had a with river the other day I'd say, Hey dude, you gotta help me take the trash out. Okay. 9 year old boy. And yeah, 48:28 Speaker 3: yeah. Said, go grab that hatchet please. And he's like, all right. 48:31 Speaker 3: I said, see this dresser that your mom has had and she hasn't done anything with and it's been outside. We need to stuff it into there. So beat the hell out of it, please. Really? Boy's dream. Yeah, 48:42 Speaker 3: like, yes. And then his mom gets mad at him. Why are you doing that? Like, let 48:47 Speaker 3: him be a boy. He needs to break stuff. 48:50 Speaker 3: He needs loud noises. He needs to break stuff. He put his baseball helmet on because you know that thing was going go bounce 48:55 Speaker 3: back in the head. 48:58 Speaker 3: We were safe and he had a blast just 49:00 Speaker 3: crushing something. 49:02 Speaker 3: Pay for that. You don't know those escape rooms, right? You literally pay money to just take a sledgehammer and beat the hell out of a car. 49:09 Speaker 4: Like 49:10 Speaker 4: a scream ringer or something. Let 49:12 Speaker 4: boys be boys baby. 49:14 Speaker 4: It's funny, you 49:16 Speaker 4: did that with River and so my son, my 4 year old has been mouthing off to my wife and we can always tell when he gets to the point where he just wants to be with dad. I brought him in here yesterday or the other day, cut him a shirt. Was 49:28 Speaker 4: like, You want to work out with dad today? And it just happened to me the day that the videographer were here, so we made it into a real, wasn't even like necessarily planned, but 49:36 Speaker 4: I took him to the gym, he sees all the videos, dude, it lit him up. So all that being said, I'm gonna get a hotel with him on Saturday, just me and him, 49:44 Speaker 4: and spend some time with my dude. It's like, dude, that's all he wants. He lit up. He just wants to be around dad. Remember at 4? Mom sucks, dude. Don't be around dad. For a boy? Yeah. Absolutely. Girls girls suck. I want dad. I was always bugging my mom. Mom, can we play catch with me? And my mom was like, it's cool. 50:01 Speaker 3: She tried, but she 50:03 Speaker 3: tried, but I still couldn't really throw very hard. She'd read it a poem. Yeah. Hate me. She's like, I kissed what you don't love homework? 50:11 Speaker 3: That's why you're so smart, bro. Yeah. He probably is. I mean, I was raised by yes. Yes. Anyway. 50:17 Speaker 3: But yeah. Yeah. Yeah. Boys need to just go break stuff and do physical things. Like, they just need physical 50:22 Speaker 3: any physical things. I was always best studying. My mom even would 50:27 Speaker 3: just tell me, it's like, alright, here's the tennis ball. I had to study even as a little kid just bouncing a ball against a wall, standing there. 50:34 Speaker 3: I was way smarter 50:35 Speaker 3: just because I had, like, I need to just motion, like, for my brain to work. Voice for sure. Even like speaking at meetings, 50:44 Speaker 3: when I 1st started doing that, I was like, oh damn, I gotta stand at the podium. And then I remember the 1st time I had to speak, I was up seated. 50:51 Speaker 3: I was like, oh, that's gonna be so easy. Seated way harder, way harder because I was just stationary. Was doing like this and I'm not, 50:58 Speaker 3: I don't know. My brain works better 1 on the fly walking around the phone. 51:04 Speaker 4: Motion creates emotion. 51:06 Speaker 3: Object 51:07 Speaker 3: in rest tends to stay in rest and object in motion tends to stay- In motion. So 51:13 Speaker 3: if you're being lazy, just get up and do something and you probably 51:17 Speaker 3: do more things. Make 51:19 Speaker 4: your bed. That Spinning down the hill and starts moving faster. 51:22 Speaker 4: So that is the GLP-1s. 51:25 Speaker 4: Everybody wants the GLP-1s. 51:26 Speaker 4: Again, our vote is, very few people even need your appetite. Like I said, I'll use it for some people if they need to lose a lot of weight, but other than that is the king of the castle. There's a reason it's so sought after by everybody. 51:40 Speaker 4: I hope this helps. Anything else you got? That's it. Hope you guys enjoyed that. Give us some feedback. Always, next is a Q and A. We will be sending that on the story. And man, we read every 1 of your comments, man. We appreciate you guys. So thank you for getting us to 300,000. 51:56 Speaker 4: Obviously, it's a big deal. You did that, not us. So we appreciate you. 52:00 Speaker 4: That's all we got. 52:01 Speaker 3: Later. Good night.